慢性乙型肝炎患者肝组织病理研究  

Study on pathology of liver tissue in patients with chronic hepatitis B

作　　者：马科[1] 丁红方[1] 黄加权[1] 宁琴[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《内科急危重症杂志》2012年第3期156-158,共3页Journal of Critical Care In Internal Medicine

基　　金：中国肝炎防治基金会王宝恩肝纤维化研究基金(No:20090025)

摘　　要：目的:探讨慢性乙型肝炎(CHB)患者临床表现和病理诊断的相关性。方法:收集30例CHB患者的临床资料,分析临床表现与病理诊断的相关性。结果:肝组织的炎症和纤维化程度的相关性显著(r=0.659,P<0.01),白蛋白/球蛋白比值(A/G)与肝脏炎症和纤维化分级显著负相关(r=-0.368,P<0.05;r=-0.401,P<0.05)。年龄、性别及其他化验指标如ALT、AST、TP、ALB、GLO、TBil、PLT、PT、PTA、门静脉宽度、脾脏厚度等与肝组织炎症和纤维化分级无显著相关性(P>0.05)。结论:慢性乙型肝炎肝脏炎症和纤维化的严重程度密切相关,仅根据肝功能判断轻中度的CHB患者的肝脏炎症及纤维化程度有相当的局限性。Objective：To explore the relevance of clinical and pathological changes of patients with chronic hepatitis B （CHB）. Methods：Clinical data of 30 cases with CHB were collected and the relevance of clinical and pathological changes was analyzed. Results ： There was a significant correlation between the grade of hepatic inflammation and fibrosis stages （r =0.659 ,P 〈0.01 ）. The negative correlation of albumin and globulin ratio （A/G） with the grade of hepatic inflammation and fibrosis stages were found （ r = - 0.368,P 〈 0.05 ; r = - 0. 401, P 〈 0.05 ）. There was no significant correlation between age, sex, ALT, AST, TP, ALB, GLO, TBil, PLT, PT, PTA, the width of portal vein, the thickness of spleen and the grade of hepatic inflammation and fibrosis stages （P 〉 0.05 ）. Conclusions ： The grade of hepatic inflammation is closely correlated with the fibrosis stages in patients with CHB. There is a considerable limitation only to judge mild or moderate inflammation and fibrosis of the liver according to liver function.

关 键 词：慢性乙型肝炎 肝功能 肝活检 肝纤维化 

分 类 号：R512.62[医药卫生—内科学]