三联吡啶钌复合膜修饰电极电化学发光法测定马来酸氯苯那敏  

Electrochemiluminescence Determination of Chlorpheniramine Maleate with Tri-(2,2′-bipyridyl)ruthenium Composite Film Modified Electrode

作　　者：张真真[1] 傅崇岗[1] 王立新[2] 

机构地区：[1]聊城大学化学化工学院,聊城252059 [2]聊城大学传媒技术学院,聊城252059

出　　处：《理化检验（化学分册）》2012年第6期660-663,共4页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：国家自然科学基金(20675036);山东省自然科学基金(Y2006B04)

摘　　要：以氧化铟锡(ITO)导电玻璃为基质,研制了一种SiO2/Ppy/PSS/Ru(bpy)32+复合膜修饰电极。在pH 8.00磷酸盐缓冲溶液中,马来酸氯苯那敏(CM)在修饰电极的电化学发光强度(ECL)有强增敏作用,据此建立了一种灵敏地测定马来酸氯苯那敏的电化学发光的方法。其ECL增加程度与CM的浓度在30～100μmol.L-1之间呈线性关系。方法的检出限(3S/N)为9.0×10-2μmol.L-1。对2.0μmol.L-1马来酸氯苯那敏标准溶液连续测定11次,测定值的相对标准偏差为1.3%。方法用于维C银翘片中马来酸氯苯那敏的测定,回收率在96.5%～98.8%之间。A SiOz/Ppy/PSS/Ru（bpy）3^2＋ composite film modified electrode was fabricated using indium tin oxide （ITO） conductive glass as the substrate. Based on the significant enhancement of electrochemiluminescence of chlorpheniramine maleate （CM） at the composite film modified electrode in a PBS of pH 8. 00, a highly sensitive eiectrochemiluminescence （ECL） method was proposed for the determination of CM. Linear relationship between magnitude of enhancement of ECL intensity and concentration of CM was obtained in the range of 30-- 100 ffmol ~ L 1, with value of detection limit （3S/N） for CM of 9.0×10^-2mol·L^-1Values of RSD （n 11） found with a same modified electrode in successive determinations of 2.0μmol·L CM standard solution was 1. 3Y0. The proposed method was applied to the determination of CM in ＂Vitamin C Yinqiao＂ tablet, giving values of recovery in the range of 96.5%-98.8%

关 键 词：电化学发光法 马来酸氯苯那敏 三联吡啶钌 

分 类 号：O657.1[理学—分析化学]