亲核取代反应在综合有机化学实验中的设计与实施  

Nucleophilic Substitution Reaction in Design and Practice of A Comprehensive Organic Chemistry Experiment

作　　者：张红萍[1] 马文伟[1] 吴凤艳[1] 

机构地区：[1]邵阳学院生物与化学工程系,湖南邵阳422000

出　　处：《邵阳学院学报（自然科学版）》2012年第2期57-60,共4页Journal of Shaoyang University：Natural Science Edition

基　　金：邵阳学院研究项目(2011JG11)资助

摘　　要：设计了以亲核取代反应为原理合成2,5-二甲基-2,5-二氯己烷的综合有机化学实验.在合成的基础上,通过对原料和产物的熔点测定、溶解性比较以及薄层层析分析,巩固了学生的基本操作技能,加深了对实验原理的认识,培养了学生独立思考和探索的精神.实践证明,该实验的实施收到了良好的教学效果.A comprehensive organic chemistry experiment was designed with nucleophilic substitution reaction as principle to synthesize 2,5-dichloro-2,5-dimethylhexane. On the base of synthesis, via melting point testing, comparison of solubility and TLC analysis, the students＂ basieal operating skill and understanding of experiment principle were strengthen, and their abilities of indepen- dent thinking and research were cultivated as well. The practice of the experiment resulted in a good teaching effect.

关 键 词：亲核取代反应 综合实验 设计 实施 

分 类 号：O6-3[理学—化学]