GnRH-a和孕三烯酮预防子宫内膜异位症术后复发的对比研究  

GnRH-a and gestrinone to prevent endometrial endometriosis recurrence

作　　者：冯淑群[1] 

机构地区：[1]宁波市妇女儿童医院四病区,浙江宁波315010

出　　处：《中国现代医生》2012年第16期39-40,共2页China Modern Doctor

摘　　要：目的观察GnRH-a和孕三烯酮预防子宫内膜异位症术后的疗效和不良反应、复发情况。方法选取149例我院2007年6月～2009年6月住院经B超和手术治疗的子宫内膜异位症患者,随机分成GnRH-a组96例和孕三烯酮组53例,比较两组的疗效及妊娠率、不良反应情况。结果 GnRH-a组显效率、改善率与对照组比较差异无统计学意义,但GnRH-a组的复发率明显低于对照组,差异有统计学意义(P<0.05)。根据r-AFS分期显示,Ⅰ期、Ⅱ期患者的妊娠率显著高于Ⅲ期、Ⅳ期患者,差异有统计学意义(P<0.01)。GnRH-a组1例出现体重增加,1例出现阴道干涩,不良反应发生率明显低于孕三烯酮组。结论 GnRH-a预防子宫内膜异位症术后复发疗效满意,安全可靠,疗效优于孕三烯酮,值得临床推广使用。Objective To observe efficacy and adverse effects and recurrence of GnRH-a and gestrinone in prevention of endometriosis. Methods A total of 149 patients in our hospital was hospitalized on June 2007 June 2009 by B ultrasound and surgical treatment of endometriosis patients were randomly divided into two groups of GnRH-a group of 96 cases, gestrinone group 53 eases, two groups were compared the efficacy and pregnancy rate of adverse reactions. Results Of GnRH-a group of remarkable efficiency, the rate of improvement with the control group the difference was not significant, but the GnRH-a group the recurrence rate was significantly.lower than the control group, the difference was significant （P 〈 0.05）. r-AFS stage, phase I , Phase Ⅱ in patients with pregnancy rate was significantly higher than in stage Ⅲ 、Ⅳ, pa- tients, the difference was significant （P 〈 0.01）. GnRH-a group 1 case of weight gain, and one cases of vaginal dryness, and the incidence of adverse reactions was significantly lower than the gestrinone group. Conclusion GnRH-a to prevent en- dometriosis postoperative recurrence results were satisfactory, safe and reliable, low recurrence rate, the effective than gestrinone, is worthy of clinical use.

关 键 词：子宫内膜异位症 GNRH-A 孕三烯酮 复发 

分 类 号：R711.71[医药卫生—妇产科学]