血清IgE水平对于不同类型冠心病的意义  

The significance of serum IgE levels for different types of coronary atherosclerotic heart diseases

作　　者：林艳[1,2] 徐其渊[1,2] 项美香[3] 

机构地区：[1]浙江大学医学院附属第二医院(滨江院区) [2]浙江省杭州市滨江医院心内科,浙江杭州310000 [3]浙江大学医学院附属第二医院心内科,浙江杭州310000

出　　处：《中国现代医生》2012年第17期39-42,共4页China Modern Doctor

基　　金：浙江省科技计划项目(2007C13058)

摘　　要：目的探讨IgE水平在不同类型冠心病中的意义。方法符合入选标准的患者按造影结果分为冠心病组(CHD,n=147)和非冠心病组(non-CHD,n=93),其中CHD组又分为稳定型心绞痛组(SAP,n=31)、不稳定型心绞痛组(UAP,n=83)和急性心肌梗死组(AMI,n=33)。用酶联免疫分析法测定血清IgE水平。结果 CHD组血清IgE高于non-CHD组(99.55±9.84 vs 62.21±5.69,P<0.01),多重线性回归模型提示仍有统计学意义(P<0.05)。IgE水平(IU/mL):AMI组(133.63±26.28),UAP组(97.72±12.41),SAP组(68.18±15.76)。AMI组依次高于UAP组(P>0.05)、SAP组(P<0.01)和non-CHD组(P<0.01)。UAP组依次高于SAP组和non-CHD组(P均<0.05)。结论 IgE是提示冠脉斑块稳定性的一个独立的生化指标,其可能在冠心病的发病中起着一定的作用。Objective To establish a link between serum immunoglobulin E （IgE） levels and different stages of coronary atherosclerotic artery diseases. Methods All 240 enrolled patients were derided into CHD group （n = 147） and non-CHD group （n = 93） according to the results of angiography. The CHD group was subgrouped into those with acute myocardial infarction （AMI, n -- 33） and those with unstable or stable angina pectoris （UAP, n = 83, and SAP, n = 31）. IgE was mea- sured by fluorescence enzyme immunoassay while other biomarkers were measured by enzymatic methods. Results Com- pared with non-CHD subjects, serum IgE levels were higher in CHD patients （99.55±9.84 vs 62.21±5.69 IU/mL, P 〈 0.01）, it remained significantly higher in a multiple linear regression test after adjusting for all confounding factors （P 〈 0.05）. IgE levels were nearly doubled in AMI patients as compared with non-CHD patients （133.63±26.28 vs 62.21±5.69 IU/mL, P 〈 0.01）, and higher than in UAP patients （97.72±12.41 IU/mL, P 〉 0.05） or SAP patients （68.18±15.76 IU/mL, P 〈 0.01）. UAP patients had significantly higher IgE levels than SAP patients （P 〈 0.05） or non-CHD patients （P 〈 0.05）. Pearson＇ s correlation test revealed that serum IgE levels correlated significantly only with fasting blood glucose levels. Conclusion Our observations suggest that serum IgE is an independent biomarker for coronary plaque stability, which provides a new direction in further research of the mechanisms of atherosclerosis.

关 键 词：免疫球蛋白E 冠状动脉粥样硬化性心脏病 肥大细胞 

分 类 号：R541.4[医药卫生—心血管疾病]