儿童代谢综合征患者血清炎症因子和脂联素的浓度水平及临床意义  

Clinical significance and serum concentration of inflammatory factor and adiponectin in children with metabolism syndrome

作　　者：陈秀芳[1] 管敏昌[1] 王海英[1] 邹朝春[1] 唐兰芳[1] 林丽君[1] 王惠庭[1] 

机构地区：[1]浙江省台州医院路桥院区儿科,浙江台州318050

出　　处：《中国现代医生》2012年第18期53-55,共3页China Modern Doctor

基　　金：浙江省重点科技创新团队建设项目(2010R50045)

摘　　要：目的探讨儿童代谢综合征(metabolic syndrome,MS)儿童血清炎症因子和脂联素的水平及临床意义。方法对100例正常儿童、120例单纯肥胖儿童和86例代谢综合征儿童常规体检,ELISA方法测定血清中超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和脂联素水平。结果 MS儿童hs-CRP、IL-6和TNF-α炎症因子水平高于单纯肥胖和正常儿童,差异具有显著统计学意义(P<0.05)。而代谢综合征儿童脂联素浓度低于单纯肥胖和正常儿童(P<0.05)。炎症因子hs-CRP、IL-6与体重指数BMI呈正相关,而与脂联素呈负相关。结论血清炎症因子和脂联素水平可作为判断MS病情及进展的有效指标。Objective To investigate the serum concentration of inflammatory factor and adiponectin in children with metabolite syndrome and analyze these clinical significant. Methods A total of 100 normal children, 120 children of simple obesity, and 86 children with metabolite syndrome were binged into our study and applied for standardized routine mea- surement. Hs-CRP, IL-6, TNF-α and adiponectin were detected by the method of ELISA. Results Hs-CRP, IL-6 and TNF-α levels of children with metabolic syndrome were higher than that in the simple obese children and normal children, and the differences were statistically significant （P 〈 0.05）. Different with inflammatory factors, adiponectin concentration in children with metabolic syndrome were lower than in the simple obesity group and normal control group, and the different were statistically significant （P 〈 0.05）. The correlation analysis showed that hs-CRP and IL-6 positively correlated with body mass index （BMI）, however adiponectin negatively correlated with BMI. Conclusion The serum levels of inflammatory.factors and adiponectin levels can be used as an effective indicator for MS.

关 键 词：代谢综合征 儿童 炎症因子 脂联素 

分 类 号：R725.8[医药卫生—儿科]