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作 者:赖毛华[1] 马红霞[1] 刘华[1] 宋兴华[1] 丁涛[1] 郑艳华[1]
出 处:《国际中医中药杂志》2012年第7期591-593,共3页International Journal of Traditional Chinese Medicine
基 金:广州市卫生局资助项目(项目编号:20112A011029);广东省中医药管理局资助项目(项目编号:20111260);广东省科技厅资助项目(立项未资助)
摘 要:目的 探讨脾肾阳虚型多囊卵巢综合征(polycysticovarysyndrome,PCOS)本质,寻找客观化指标。方法收集200例PCOS患者,经辨证分为脾肾阳虚组105例和非脾肾阳虚组95例,检测并比较两组患者的体重指数(BMI)、腰臀比(wHR)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)性激素水平、空腹血糖(FPG)、空腹胰岛素(FINS)、餐后2h胰岛素(2hINS)、胰岛素抵抗指数(HOMR-IR)在脾肾阳虚型与非脾肾阳虚型PCOS患者中的差异。结果脾肾阳虚组BMI(24.4±2.8)、WHR(0.88±0.07)、LH/FSH(2.02±1.06)、E2(55.84±23.87)pg/ml、HOMR—IR(2.95±1.52)、FINS(15.18±7.64)IU/ml、2biNS(59.53±40.61)1U/ml均高于非脾肾阳虚组[分别为(22.2±2.2)、(0.80±0.06)、(3.50±1.80)、(45.82±21.31)pg/ml、(1.90±1.50)、(9.93±6.59)1U/ml、(50.56±41.34)IU/ml],差异均有统计学意义(P均〈0.05);但FSH、T激素水平比较,差异无统计学意义(FSH脾肾虚组=(6.46±0.95)IU/L、FSH非脾肾阳虚组=(6.40-1.16)IU/L;T脾肾阳虚组=(0.81±0.15)μg/L、T非脾肾阳虚组=(0.72±0.13)μg,P〉0.05)。结论BMI、WHR、LH/FSH、E2、HOMR.IR、FINS、2hINS指标可作为脾肾阳虚型PCOS的客观化参考指标。Objective To explore the essence of polycystic ovary syndrome of spleen-kidney yang deficiency, and to investigate the objective standardization of TCM syndrome diagnosis of the disease. Methods Among the 200 PCOS patients, the Chinese medicine syndrome pattern was differentiated as spleen-kidney yang deficiency type (n: 105 )and Non-spleen-kidney yang deficiency type (n--95). To measure and compare their levels ofBMh WHR, sexual hormones, FINS, 2 hINS, and HOMR-IR. Results The levels of BMI (24.4±2.8), WHR (0.88±0.07), LH/FSH (2.02±1.06), E2 (55.84±23.87) pg/ml, HOMR-IR (2.95±1.52), FINS ( 15.18 ± 7.64 ) IU/ml, 2hlNS ( 59.53 ± 40.61 ) IU/ml in the group of spleen-kidney yang deficiency type were obviously higher than those[ (22.2±2.2), (0.80±0.06), (3.50±1.80), (45.82±21.31) pg/mh ( 1.90±1.50), (9.93±6.59) IU/mh (50.56±41.34) IU/ml respectively] in the group of Non-spleen-kidney yang deficiency type (P〈0.05) , but T and FSH level showed no significant difference between two groups [FSH the goupofspleerl-kidneyyangdeficiencytype= (6.46±0.95)IU/L, FSH the group of No-spleen-kidneyyangdeflciencylype= (6.40± 1.16) IU/L; Tthegroupofspleen.kidaeyyangdeficiencytype7- (0.81±0.15) μg/L, T the group of No-spleen-kidneyyangdeficiencytype= (0.72±0.13)μg/L, P〉0.05]. Conclusion BMh WHR, LI-I/FSH, E2, FINS, 2HINS, and HOMR-IR could be used as objective index in identifying the difference in between spleen-kidney yang deficiency type and Non-spleen-kidney yang deficiency type.
分 类 号:R259[医药卫生—中西医结合]
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