益气养阴、活血通脉法治疗冠心病介入术后再狭窄的临床观察  

Clinical study on the method of reinforcing qi nourishing yin and promoting blood circulation to remove blood stasis in the treatment of restenosis after percutaneous coronary intervention

作　　者：安海英[1] 郭玉红[2] 王振裕[3] 

机构地区：[1]首都医科大学附属北京中医医院心血管科,100010 [2]首都医科大学附属北京中医医院急诊科 [3]首都医科大学附属北京中医医院综合科

出　　处：《国际中医中药杂志》2012年第7期601-605,共5页International Journal of Traditional Chinese Medicine

摘　　要：目的 观察益气养阴、活血通脉法治疗冠心病介入术后再狭窄的临床疗效。方法选择2008年10月至2011年5月我院内科门诊冠心病介入术后再狭窄患者，采用随机数字表法分为两组各30例。对照组予常规西药治疗，治疗组在常规西药治疗的基础上加用益气养阴、活血通脉的中药，疗程6个月。观察患者临床症状、冠状动脉CT血管造影（cTA）、血脂等的变化。结果治疗组总有效率为93．33％，对照组为66．67％，两组总有效率比较，差异有统计学意义（X2=8．787，P〈0．05）。治疗组治疗后胸痛、胸闷、气短、乏力、口干的症状积分得到明显改善[分别为（1．07±1．01）分、（1．33±1．21）分、（1．47±1．17）分、（1．53±1．14）分、（1．53±1．01）分，（P〈0．05）]，且优于对照组[分别为（2．07±1．53）分、（2．27±1．46）分、（3．73±1．46）分、（3．73±1．87）分、（3．13±1．63）分，（P〈0．05）]。冠状动脉造影或冠状动脉CTA的结果显示，治疗组患者再狭窄的程度均未见加重或出现新的再狭窄。治疗组治疗后胆固醇（CHOL）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL．C）、低密度脂蛋白胆固醇（LDL．C）水平[分别为（4．55±0．44）mmol／L、（1．81±0．56）mmol／L、（1．26±0．38）mmol／L、（2．25±0．49）mmol／L，（P〈0．05）]均较疗前明显改善，且优于对照组治疗后CHOL、TG、LDL．C[分别为（4．86±0．63）mmol／L、（2．29±1．06）mmol／L、（2．60±0．73）mmol／L，（P〈0．05）]的水平。结论益气养阴、活血通脉法可改善患者的临床症状和血脂水平，对防治介入术后再狭窄有一定的作用。Objective To observe the clinical effects of the method of reinforcing qi, nourishing yin and promoting blood circulation to remove blood stasis in the treatment of restenosis after percutaneous coronary intervention. Methods 60 coronary heart disease patients who had accepted PCI treatment and occurred restenosis were randomly recruited into a control group and a treatment group, 30 cases in each group. The control group received conventional therapy. The treatment group was treated with conventional therapy combined with TCM of reinforcing qi, nourishing yin and promoting blood circulation to remove blood stasis. Both groups were treated for 6 months. The clinical symptoms, coronary angiography or coronary artery CTA, blood lipids were observed. Results The total effective rate was 93.33% and 66.67% in the treatment group and the control group respectively, showing statistical difference （X2=8.787, P〈0.05）.The patients＇ clinical symptoms in the treatment group were improved, such as chest pain, chest tightness, shortness of breath, fatigue, dry mouth [The scores were respectively （1.07±1.01）, （1.33 ±1.21）, （1.47± 1.17）, （1.53 ±1.14）, （1.53±0.01）, （P〈0.05） ]. The treatment group demonstrated a significantly better therapeutic results than the control group [The scores were respectively （2.07± 1.53）, （2.27±1.46）, （3.73± 1.46）, （3.73 ± 1.87）, （3.13 ± 1.63）, （P〈 0.05） ]. The results of coronary angiography or coronary artery CTA showed that the narrow degree in the treatment group was no more aggravating and it had no new restenosis. After the treatment, the level of CHOL,TG, HDL-C, LDL-C in the treatment group was improved [They were respectively （4.55 ±0.44） mmoFL, （1.81±0.56）mmol/L, （1.26±0.38） mmol/L, （2.25±0.49）mmol/L, （P〈0.05） ]. The improvement in CHOL, TG, LDL-C of the treatment group was better than that of the control group [They were respectively （4.86±0.63）mmol/L, （2.29 ±1 .06） mmol/L, （2.60±0.73

关 键 词：冠心病介入术后再狭窄 益气养阴 活血通脉法 

分 类 号：R541.4[医药卫生—心血管疾病]