尖锐湿疣患者人乳头瘤病毒检测分型结果分析  

Analysis on the genotyping results of HPV detection for 53 cases of condyloma acuminata patients

作　　者：王海清[1] 杨云[1] 张飞凤[1] 徐延香 周剑峰 

机构地区：[1]宜春学院医学院,宜春学院预防医学研究所,336000 [2]江西省铜鼓县妇幼保健院,336200 [3]江西省铜鼓县人民医院皮肤科,336200

出　　处：《实用医学杂志》2012年第13期2232-2234,共3页The Journal of Practical Medicine

基　　金：中国癌症基金会-中国生殖器疣多中心临床流行病学研究项目(编号:MED-GEN03-07V1)

摘　　要：目的:探讨尖锐湿疣(condyloma acuminata,CA)患者人乳头瘤病毒(human papillomavirus,HPV)的亚型分布与特点。方法:患者来自江西铜鼓、奉新、袁州三县区,HPV检测与分型方法为GP-PCR和基于序列分析的基因分型。结果:53例活检标本检出单一型HPV感染亚型3种共30例,其中11型15例(50.0%),6型13例(43.3%),16型2例(6.7%);总检出率56.6%(30/53),低危型(6/11型)28例占93.3%。结论:当地CA患者为HPV单一型别感染,HPV11、6型为优势亚型。Objective To explore the subtype distribution and characteristics of the HPV types of condyloma acuminata （CA） in Yichun district, Jiangxi Province. Methods The object of study was patients from Tonggu and Fengxin county and Yuanzhou district of Yichun, Jiangxi. The HPV DNA detection and genotyping was done through GP-PCR and nucleotide sequencing. Results Among 53 cases of biopsy specimen of the wart tissue collected, 30 cases were Type 3 HPV DNA subtype, 15 cases of Type 11 （50.0%）, 13 cases of Type 6 （43.3%） and 2 cases of Type 16 （6.7%）. The total positive rate was 56.6% （30/53）, and 93.3% of the cases, that is, 28 cases were low risk type （the Type 6/11 ）, Conclusion The local CA patients are HPV unitary type infection. HPV 11, 6 is the majority and is the superior subtype of CA.

关 键 词：尖锐湿疣 HPV 基因分型 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]