我院肿瘤患者287例药品不良反应报告分析  

Analysis of 287 Cases of Adverse Drug Reaction in Tumor Patients in Our Hospital

作　　者：邓燕芬[1] 庞廷媛[1] 程国华[1] 

机构地区：[1]广州医学院附属肿瘤医院,广州510095

出　　处：《中国药房》2012年第26期2470-2471,共2页China Pharmacy

摘　　要：目的:了解肿瘤患者药物使用中的药品不良反应(ADR)发生的特点及规律。方法:采用回顾性研究方法,将2009-2011年间收集的我院287例住院肿瘤患者用药的ADR报告,按性别、年龄、给药途径、药品品种、ADR累及器官或系统及临床表现、ADR程度等进行统计、分析。结果:ADR发生率在50岁以上中老年患者中较高(占47.39%);抗肿瘤药发生率最高(占32.06%),其次为维生素及营养药(15.68%)及抗感染类药(11.85%);92例抗肿瘤药致ADR中,以铂类和植物来源类药物引起的ADR最多,占53.26%;ADR主要临床表现为全身症状及皮肤及其附件损害,共115例,占40.07%。结论:肿瘤专科医院应重视并做好ADR的监测、分析、评价工作,特别是抗肿瘤药、营养药及抗感染3类药物的ADR监测,以保证肿瘤患者药物治疗安全有效。OBJECTIVE： To study the characteristics and regularity of adverse drug reactions （ADR） in tumor patients. METHODS： In retrospective study, ADR reports of 287 tumor patients collected from our hospital during 2009 to 2011 were analyzed statistically in terms of gender, age, route of administration, drug types, organs or system involved in ADR, clinical manifestation and degree of ADR. RESULTS： Among the incidence of ADR, the incidence was higher in the elderly patients over age 50 （accounting for 47.39% ） ; 32.06% of ADR were induced by antitumor drug, followed by nutritional medicine （15.68%） and anti-infective drugs （11.85%）; among 92 ADR cases caused by antitumor drugs, platinum and herbs accounted for the highest proportion （53.26%）. The major manifestations were general symptom and the damages of skin and appendants in 115 cases, accounting for 40.07%. CONCLUSION： Tumor hospital should pay attention to ADR monitoring, analysis, evaluation, especially antitumor drugs, nutritional medicine and anti-infection agents to ensure the safe and effective drug treatment of tumor patients.

关 键 词：肿瘤患者 药物使用 药品不良反应 

分 类 号：R969.3[医药卫生—药理学]