210例外阴阴道假丝酵母菌病分组治疗的疗效比较  

Comparison of curative effect of grouping treatment for 210 cases with vulvovaginal candidiasis

作　　者：欧阳慧[1] 唐伟琼[1] 

机构地区：[1]广州军区广州总医院妇产科,广东广州510010

出　　处：《中国妇幼保健》2012年第18期2796-2798,共3页Maternal and Child Health Care of China

摘　　要：目的:观察与评价单纯用药与联合用药治疗外阴阴道假丝酵母菌病(VVC)的临床疗效。方法:根据Soble分类,将210例VVC患者随机分为两组,A组采用硝酸咪康唑阴道软胶囊1 200 mg治疗2个疗程(单纯用药组),B组采用硝酸咪康唑阴道软胶囊1 200 mg+伊曲康唑胶囊治疗2个疗程(联合用药组),于治疗后第7～14天和30天进行疗效评价。结果:210例患者中按要求复诊177例,临床有效率A组为87.7%,B组为94.8%,差异有统计学意义(P<0.05);真菌学转阴率A组为95.1%,B组为98.9%;用药依从性A组为77.9%,B组为90.6%,差异有统计学意义(P<0.05);30天复诊复发率A组为16.9%,B组为7.7%,P<0.05,差异有统计学意义。结论:单纯用药与联合用药均能有效治疗VVC;联合用药在临床有效率与依从性上优于单纯用药组;联合口服用药的复发率低于阴道单纯用药。Objective： To observe and evaluate the clinical effects of monotherapy and combined therapy for treatment of vulvovagi- hal candidiasis （VVC） . Methods ： Two hundred and ten patients with VVC were randomly divided into two groups according to Soble clas- sification, the patients in group A were treated with putting mieonazole nitrate soft capsule （1 200 rag） into vagina for two courses of treat- ment （monotherapy group）, while the patients in group B were treated with putting mieonazole nitrate soft capsule （1 200 mg） combined with itraeonazole capsule into vagina for two courses of treatment （combined therapy group） ; the curative effects at 7 - 14 days and 30 days after treatment were evaluated. Results： Among 210 patients, 177 patients came back for return visit, the clinical effective rates in group A and group B were 87. 7% and 94. 8% , respectively, there was statistically significant difference between the two groups （P 〈 0. 05 ） ; the negative conversion rates of fungal examination in group A and group B were 95.1% and 98.9% , respeetively; the medication compliances in group A and group B were 77. 9% and 90. 6%, respectively, there was statistically significant difference between the two groups （P 〈 0. 05 ） ; the readmission rates at 30 days after treatment in group A and group B were 16. 9% and 7.7%, respectively, there was statistically significant difference between the two groups. Conclusion： Both monotherapy and combined therapy can cure VVC effectively; the clinical effective rate and compliance of combined therapy are superior to those of monotherapy; the recurrence rate of combined oral administration is lower than that of simple vaginal application of drugs.

关 键 词：硝酸咪康唑 伊曲康唑 有效性 依从性 

分 类 号：R711.3[医药卫生—妇产科学]