Relationship between HLA-DR gene polymorphisms and outcomes of hepatitis B viral infections:A meta-analysis  

作　　者：Ze-Hui Yan Yi Fan Xiao-Hong Wang Qing Mao Guo-Hong Deng Yu-Ming Wang 

机构地区：[1]Institute of Infectious Diseases,South-west Hospital,the Third Military Medical University,Chongqing 400038,China

出　　处：《World Journal of Gastroenterology》2012年第24期3119-3128,共10页世界胃肠病学杂志（英文版）

基　　金：Supported by The National Natural Science Foundation of China,No.30972598;National Basic Research Program of China (973 Program),No.2007CB512903;the State Key Project Specialized for Infectious Diseases,No.2008ZX10002-007

摘　　要：AIM:To assess the rigorous relationship between human leukocyte antigens(HLA)-DR alleles and outcomes of hepatitis B virus(HBV) infections by means of metaanalysis.METHODS:Medline/PubMed,EMBASE,CNKI and VIP were searched to identify relevant studies.Study quality was evaluated using the Newcastle-Ottawa Scale.Odds ratios(OR) and 95% confidence interval(95% CI) were pooled using Stata 11.0.Subgroup analyses were performed by ethnicity.Heterogeneity and publication bias analyses were performed to validate the credibility.RESULTS:A total of 2609 patients with chronic hepatitis B and 2606 controls spontaneously recovering from prior HBV infection were included.Meta-analysis showed that HLA-DR*04(OR = 0.72,95% CI:0.60-0.85) and DR*13(OR = 0.27,95% CI:0.19-0.37) alleles were significantly associated with HBV clearance while patients carrying HLA-DR*03(OR = 1.47,95% CI:1.16-1.87) or DR*07(OR = 1.59,95% CI:1.24-2.03) alleles had a significantly increased risk of chronic HBV persistence.For the HLA-DR*01 polymorphism,a significantly association with HBV clearance was found in Chinese Han group(OR = 0.48,95% CI:0.26-0.86),but not found in other ethnic groups(P = 0.191).For other polymorphisms,no association with the HBV infection outcome was found.CONCLUSION:HLA-DR*04 and DR*13 alleles may be the protective factors for HBV clearance and HLADR*03,and DR*07 alleles may be the risk factors for HBV persistence.AIM：To assess the rigorous relationship between human leukocyte antigens（HLA）-DR alleles and outcomes of hepatitis B virus（HBV） infections by means of metaanalysis.METHODS：Medline/PubMed,EMBASE,CNKI and VIP were searched to identify relevant studies.Study quality was evaluated using the Newcastle-Ottawa Scale.Odds ratios（OR） and 95% confidence interval（95% CI） were pooled using Stata 11.0.Subgroup analyses were performed by ethnicity.Heterogeneity and publication bias analyses were performed to validate the credibility.RESULTS：A total of 2609 patients with chronic hepatitis B and 2606 controls spontaneously recovering from prior HBV infection were included.Meta-analysis showed that HLA-DR＊04（OR = 0.72,95% CI：0.60-0.85） and DR＊13（OR = 0.27,95% CI：0.19-0.37） alleles were significantly associated with HBV clearance while patients carrying HLA-DR＊03（OR = 1.47,95% CI：1.16-1.87） or DR＊07（OR = 1.59,95% CI：1.24-2.03） alleles had a significantly increased risk of chronic HBV persistence.For the HLA-DR＊01 polymorphism,a significantly association with HBV clearance was found in Chinese Han group（OR = 0.48,95% CI：0.26-0.86）,but not found in other ethnic groups（P = 0.191）.For other polymorphisms,no association with the HBV infection outcome was found.CONCLUSION：HLA-DR＊04 and DR＊13 alleles may be the protective factors for HBV clearance and HLADR＊03,and DR＊07 alleles may be the risk factors for HBV persistence.

关 键 词：Hepatitis B virus Human leukocyte anti-gens META-ANALYSIS POLYMORPHISM 

分 类 号：Q346.5[生物学—遗传学] Q78