槌果藤对佐剂性关节炎大鼠模型外周血中细胞因子影响的研究  

Effects on TNF-α in the Adjuvant Arthritis Rat Model by the Capparis Spinosal

作　　者：周晓涛[1,2] 周文涛[1,3] 马秀敏[1,2] 丁剑冰[1,2] 朱明[2] 马骏[4] 薛志琴[2] 王亚男[2] 田树革 

机构地区：[1]新疆名医名药与特色方剂学重点实验室,新疆乌鲁木齐830011 [2]新疆医科大学基础医学院,新疆乌鲁木齐830011 [3]新疆医科大学第五附属医院,新疆乌鲁木齐830011 [4]新疆医科大学附属中医医院,新疆乌鲁木齐830000

出　　处：《时珍国医国药》2012年第6期1382-1384,共3页Lishizhen Medicine and Materia Medica Research

基　　金：新疆维吾尔自治区自然科学基金(No.200821129);新疆维吾尔自治区教育厅重点项目(No.XJEDU2008I17);新疆维吾尔高技术研发项目(No.PT0708)

摘　　要：目的观察槌果藤对佐剂性关节炎大鼠模型外周血中细胞因子TNF-α及sICAM-1的影响。方法建立佐剂性关节炎大鼠模型,观察槌果藤对AA大鼠足肿胀、踝关节组织病理变化及血清中促炎细胞因子TNF-α及sICAM-1水平的影响。结果槌果藤能有效抑制关节肿胀及减轻炎症的发展,降低佐剂性关节炎大鼠血清中促炎细胞因子TNF-α及sI-CAM-1的水平。结论槌果藤抗RA作用与抑制促炎细胞因子TNF-α及sICAM-1的水平有关。Objective To observe the the effects on TNF - αand slCAM - 1 in the adjuvant arthritis（AA） rat model by the Cap- paris Spinosal. Methods After establishing AA rat model, the Capparis Spinosalg antiarthritic effects and mechanism against RA were studied through observing the changes of ankle swelling, pathology of anklebone and levels of TNF - αand sICAM - 1 after medication. Results The Capparis Spinosal could effectively inhibits articular swelling, decrease inflammatory and down regulate the content of TNF -α in the serum of AA rats. Conclusion The Capparis Spinosal has good antiarthritic effects and the possible mechanism may be related to its down regulation of TNF -αand sICAM - 1.

关 键 词：槌果藤 类风湿性关节炎 肿瘤坏死因子Α 可溶性免疫细胞粘附分子 

分 类 号：R285.5[医药卫生—中药学]