甘草酸、甘草次酸衍生物的合成及生物活性研究进展  

Advances in Studies on The Synthesis of Glycyrrhizic acid,Glycyrrhetinic Acid Derivatives and Their Biological Activities

作　　者：雍建平[1] 

机构地区：[1]宁夏医科大学公共卫生学院,宁夏银川750004

出　　处：《时珍国医国药》2012年第6期1495-1498,共4页Lishizhen Medicine and Materia Medica Research

基　　金：宁夏回族自治区自然科学基金(No.NZ10108);宁夏医科大学博士建设开放课题(No.KF2010-12);宁夏医科大学校级项目(No.XM201010)

摘　　要：甘草酸、甘草次酸是甘草中最重要的活性成分,具有广泛的生物活性,尤其是其衍生物具有显著的抗炎、抗乙肝病毒、抗艾滋病毒等活性。近年来国内外专家合成了许多结构各异的甘草酸、甘草次酸衍生物,并研究了其相关的药理活性。文章综述了近年国内外对甘草酸、甘草次酸衍生物合成及活性研究所取得的新进展。Glycyrrhizic acid, glycyrrhetinie acid are the most important active ingredients in the Licorice root, possessing wide range of pharmacological and biological activities. Especially their derivatives show the remarkable anti - inflammatory, anti - he- patic and anti - HIV viruses. In this article, we reviewed the new progress in the studies on the synthesis of derivatives of glycyr- rhezic acid, glycyrrhetinic acid and their biological activities.

关 键 词：甘草酸 甘草次酸 衍生物 合成 生物活性 

分 类 号：R284.2[医药卫生—中药学]