NLRC5： a NOD-like receptor protein with many faces in immune regulation  

作　　者：Yue Zhao Feng Shao 

机构地区：[1]National Institute of Biological Sciences,7#Science Park Rd,Zhongguancun Life Science Park,Beijing 102206,China

出　　处：《Cell Research》2012年第7期1099-1101,共3页细胞研究（英文版）

摘　　要：Intracellular NOD-like receptor （NLR） proteins are believed to play important roles in innate immune detection or immune regulation, but only a few NLR proteins are functionally defined. Recent intensive studies, largely in vitro, on NLRC5 reveal multiple and controversial roles of this NLR protein in signaling regulation of both innate and adaptive immune responses. Using independently generated Nlrc5-deficient mice, two studies have now established the physiological function of NLRC5 in transcriptional control of MHC class I molecules despite that its role in innate immune signaling remains to be further clarified.

关 键 词：受体蛋白 免疫调节 NOD 先天免疫 信号调节 免疫检测 免疫反应 生理功能 

分 类 号：S476.13[农业科学—农业昆虫与害虫防治] S852.4[农业科学—植物保护]