K-Ras and mitochondria： Dangerous liaisons  

作　　者：Jiri Neuzil Jakub Rohlena Lan-Feng Dong 

机构地区：[1]Apoptosis Research Group, School of Medical Science and the Griffith Health Institute, Griffith University Gold Coast Campus, Southport, 4222 Qld, [2]Australia,Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

出　　处：《Cell Research》2012年第2期285-287,共3页细胞研究（英文版）

摘　　要：It is well documented that the K- R/IS oncogene efficiently transforms non-malignant cells, and there is some evidence for the role of mitochondria in this process. Now Peng Huang and colleagues show that K-Ras induc- tion results early on in mitochondria assuming the phenotype consistent with the so-called Warburg effect, i.e., increased glycolysis and attenuated oxidative phosphorylation. Thus the K-Ras protein capable of swift induc- tion of phenotypic changes typical of cancer cells, yet these changes are reversible, and for cells to irreversibly reach their full malignant potential a much longer K-Ras expression is required, implicating mitochondria in the longer-term effects of the on- cogene.

关 键 词：RAS基因 线粒体 联络员 危险 基因诱导 磷酸化作用 癌细胞 不可逆 

分 类 号：Q492.6[生物学—生理学] Q244