模拟不同海拔高原环境下氦氧潜水对潜水员肾功能的影响  

Effects of simulated heliox diving on the renal function of the divers at different high altitudes

作　　者：张禹[1] 孟祥恩[1] 胡慧军[1] 范丹峰[1] 赵儒钢[1] 潘晓雯[1] 

机构地区：[1]海军总医院全军高压氧治疗中心,北京100048

出　　处：《中华航海医学与高气压医学杂志》2012年第3期138-140,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：总装备部装备技术基础项目（YXSJD20101BZOI）

摘　　要：目的探讨模拟不同海拔高原环境下氦氧潜水对潜水员肾功能的影响。方法4名潜水员于高低压两用舱内，连续9d先后模拟平原、海拔3000m环境及该环境下30m潜水、海拔4000m环境及该环境下30m潜水、海拔5200m环境及该环境下30ln潜水和50m潜水。分别于实验第1天早上进舱前空腹，实验第3天3000m高原早上空腹，实验第4天3000m高原30m潜水减压返回3000m后，当天17：30晚饭前，实验第6天4000m高原30m潜水减压返回4000m后，当晚17：30晚饭前，实验第7天5200Ill高原停留1夜，早上空腹，实验第8天5200m高原50In潜水减压回到5200m后（23：00），实验第9d实验结束后出舱午餐前抽血。采用自动生化仪进行肾功能相关指标检测，包括：血肌酐、血尿素氮、血糖、血钾、血钠、血氯；连续9d留取晨起中段尿，采用尿流式细胞仪行尿常规检查。结果在完成4000nq高原30m潜水减压返回4000m后，血清肌酐及尿素氮有升高趋势，但与其他时间点比较差异均无统计学意义（P〉0．05）。各时间点潜水员的血清肌酐、尿素氮、血糖、血电解质、尿液pH值、尿密度均在正常范围内，差异无统计学意义（P〉0．05）。尿红细胞、尿白细胞、尿蛋白、尿酮体、尿糖、尿胆原，尿胆红素等检测结果均为阴性。结论本实验条件下模拟高原氦氧潜水过程对潜水员肾功能没有明显影响。Objective To investigate effects of simulated heliox diving on the renal function of the divers at different high altitudes. Methods In the dual-purpose hyperbaric and hypobaric chamber complex, 4 divers conducted a series of simulated dives for a succession of 9 days at various altitudes and under different simulated environmental conditions ： the 30 m dive at an altitude of 3 000 m, the 30 m dive at an altitude of 4000 m, and the 30 m and 50 m dives at an altitude of 5 200 m. Blood samples were taken respectively at the following time points ： i.e. on the morning of the first day of the experiment before they entered the chamber on an empty stomach ; on the morning of the third day of the experiment at an altitude of 3 000 m also on an empty stomach; at 17：30 pm before supper on the fourth day of the experiment, when the divers were decompressed and returned to the surface at an altitude of 3 000 m, upon completion of the 30 m-dive ; at 17 ： 30 pm before supper on the sixth day, when the divers returned to the surface at an altitude of 4 000 m, upon completion of the 30 m-dive; on the morning of the seventh day on an empty stomach, the divers stayed overnight at an altitude of 5 200 m. Related renal function indices, such as serum creatinine, serum urea nitrogen, blood glucose, K＋ , Na＋ , C1- were measured with biochemical auto-analyzer at 1~t, 3ra, 4th , 6th, 7＇h, 8t~ and 9＇h days respectively. Morning midstream urine samples were collected for successive 9 days and routine urine examinations were made with urine flow cytometry. Results Upon decompression to the surface at an altitude of 4 000 m after the 30-m dive, serum creatinine and blood urea nitrogen tended to elevate to a certain degree, but without statistical significance （P 〉 0.05）. Serum creatinine, blood urea nitrogen, blood glucose, electrolytes,urine pH, K ~ , Na ＋ , C1- , urine specific gravity detected at different time points were all within normal range, without statistical significance （ P 〉 0.05 ）. The detectio

关 键 词：高原 氦氧潜水 肾功能 

分 类 号：R84[医药卫生—航空、航天与航海医学]