胸腔灌洗法综合治疗犬海水浸泡胸部开放伤的实验研究  

Experimental research of thoracic lavage for the treatment of open chest injury coupled with seawater immersion

作　　者：陆中元[1] 陈兵[1] 朱震[1] 张骏[1] 李雄伟[1] 陆昕冶[1] 

机构地区：[1]解放军第一一七医院胸心外科,杭州310013

出　　处：《中华航海医学与高气压医学杂志》2012年第3期147-150,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：南京军区医药卫生科研基金课题（08MDl48）

摘　　要：目的探讨加用胸腔灌洗法对犬海水浸泡胸部开放伤的治疗效果。方法采用数字表法将成年杂交犬随机分为实验组（胸腔灌洗组）和对照组（常规救治组），每组10只，制成海水浸泡胸部开放伤动物模型。对照组采用常规救治，实验组在常规救治的基础上给予胸腔灌洗。观察2组部分血生化指标及肺组织病理改变的情况。结果伤后1．Oh，对照组血清钠为（157．80±3．70）mmoL／L，实验组为（146．25±4．14）mmoL／L，2组比较差异有统计学意义（P〈O．05）；对照组渗透压为（345．46±6．18）mm0L／L，实验组为（320．53±6．91）mm0L／L，2组比较差异有统计学意义（P〈0．05）；在伤后8h，对照组血清钠为（146．80±2．87）mmoL／L，实验组为（138．50±3．21）mmoL／L，2组比较差异有统计学意义（P〈0．05）；对照组渗透压为（331．42±4．68）mmoL／L，实验组为（312．24±5．23）mmoL／L，2组比较差异有统计学意义（P〈0．01）。海水浸泡胸部开放伤后，2组血清钠及血浆渗透压明显升高，经过治疗血清钠及血浆渗透压均降低，其中实验组的改善更明显，实验组肺组织的病理改变程度也小于对照组。结论加用胸醉灌济法县一种治疗海水浔洵胸部开放伤的有效方法。Objective To explore therapeutic effects of thoracic lavage for the treatment of open chest injury coupled with seawater immersion in dogs. Methods Adult mongrel dogs were randomly divided into the experimental group （ the thoracic lavage group ） and the control group （ the routine treatment group ）, each consisting of 10 dogs. The animal model of open chest injury coupled with seawater immersion was developed in the laboratory. The control group received routine medical treatment, while the experimental group was administered with thoracic lavage in addition to routine medical treatment. Pathological changes in the internal environment and pulmonary tissues of the animals in the 2 groups were observed. Results One hour after injury, serum sodium of the control group was （ 157.80±3.70） mmol/L, and that of the experimental group was （146.25±4.14） mmol/L （P 〈 0.05 ）. Osmotic pressure of the control group was （345.46±6.18 ） mmol/L, and that of the experimental group was （320.53±6.91 ） mmol/L （P 〈 0.05）. Eight hours after injury, serum sodium of the control group was （ 146.80±2.87） retool/L, and that of the experimental group was （ 138.5±3.21 ） mmol/L （P 〈 0.05 ）. Osmotic pressure of the control group was （331.42±4.68 ） mmol/L, and that of the experimental group was （312.24±5.23） mmol/L （P 〈0.01 ）. Following development of open chest injury coupled with seawater immersion, serum sodium and plasma osmotic pressure of both groups increased significantly. After treatment, serum sodium and plasma osmotic pressure of both groups all decreased, with the indices of the experimental group decreased more significantly. There were less pathological changes in the pulmonary tissue of the experimental group, when compared with the control group. Conclusions Thoracic lavage was effective for the treatment of open chest injury coupled with seawater immersion.

关 键 词：胸部开放伤 海水浸泡伤 胸腔灌洗 血浆渗透压 

分 类 号：R83[医药卫生—航空、航天与航海医学]