光甘草定微乳的制备及质量评价  

Preparation and Quality Evaluation of Glabridin Microemulsion

作　　者：刘珊珊[1] 范玉涵[1] 任全霞[1] 郭小娜[1] 陈文[1] 

机构地区：[1]石河子大学药学院/新疆特种植物药资源教育部重点实验室,石河子832000

出　　处：《石河子大学学报（自然科学版）》2012年第2期229-234,共6页Journal of Shihezi University(Natural Science)

基　　金：新疆兵团重点科技攻关计划(社会发展科技攻关)项目(2009GG47)

摘　　要：以光甘草定为模型药物,筛选光甘草定O/W型微乳制剂的处方并对其稳定性及质量进行考察。通过溶解度实验及伪三元相图的建立,筛选光甘草定微乳的组成。采用HPLC法测定处方中药物的含量并对其稳定性进行考察。光甘草定微乳的组成为乳化剂与助乳化剂的比例为1∶1(w/w),混合乳化剂为25.26%,油相为6.30%,水相为71.35%。在高速离心、高温、强光照射下无分层,无絮凝或药物析出,微乳的性状、含量均无明显变化。光甘草定微乳能有效改善药物的溶解度,制备方法简单可行,且稳定性良好。To design the formulation for O/W microemulsion of Glabridin and evaluate its stability and quality. The formulation was established through solubility experiments and pseudoternary phase diagrams. The content and stability were evaluated by HPLC assay. The optimal formulation was composed of 25.26 % mixed-emulsifier（ 1 ： 1 emulsifier and co--emulsifier）, 6.30 oil phase and 71.35% water phase. The appearance and average Glabridin content changed insignificantly after 10 days of high speed centrifuge （5000r/min） ,high temperature （60 ℃） ,low temperature （4℃ ） ,and illumination （45001x）. Glabridin microe- mulsion can effectively improve drug solubility and its preparation method is simple and feasible. Meanwhile. the stability of microemulsion is sound.

关 键 词：光甘草定 微乳 制备 质量评价 

分 类 号：R944.17[医药卫生—药剂学]