重复经颅磁刺激对慢性精神分裂症阴性症状的疗效  

Effectiveness of repetitive transcranial magnetic stimulation on negative symptoms of patients with chronic schizophrenia

作　　者：吴越[1] 季萍[1] 汤莉[1] 杨国平[1] 

机构地区：[1]无锡市精神卫生中心老年精神科,江苏无锡214151

出　　处：《中国康复》2012年第3期227-228,共2页Chinese Journal of Rehabilitation

摘　　要：目的:观察重复经颅磁刺激(rTMS)对慢性精神分裂症阴性症状的临床疗效及安全性。方法:将48例住院慢性精神分裂症患者随机分为rTMS真刺激组(研究组)24例和rTMS假刺激组(对照组)24例,2组在维持原有抗精神病药物种类及剂量不变的基础上,研究组给予经左侧前额叶背外侧皮质高频rTMS刺激;对照组给予假刺激。于治疗前及治疗4周末应用阳性与阴性症状量表(PANSS)和阴性症状量表(SANS)评定疗效。结果:治疗过程中2组均未见严重不良反应。治疗4周后,2组PANSS和SANS评分较治疗前明显降低(P<0.05,0.01),2组间比较,研究组下降更明显(P<0.05)。结论:rTMS联合抗精神病药能有效改善慢性精神分裂症的阴性症状。Objective： To observe the effect and safety of repetitive transcranial magnetic stimulation （rTMS） on negative symptoms of patients with chronic schizophrenia. Methods： 48 patients with chronic schizophrenia were randomly divided into real rTMS group （study group） and sham rTMS group （control group） ,with 24 cases in every group. Study group received real rTMS sessions over 4 weeks to the left dorsolateral prefrontal cortex, while the control group received sham rTMS treatment. All patients were given anti-psychotic drug treatment. Both groups were assessed by using Positive and Negative Syndromes Scale （PANSS）, and scale for the Assessment of Negative Symptoms （SANS）. Results： There were no severe adverse events in the treatment. After 4 weeks of treatment, scores of PANSS and SANS scales in study group were significantly lower than those before treatment and those in control group （P〈0.05）. Conclusion： Combination of rTMS and antipsychotics is an effective method in treating negative symptoms of patients with chronic schizophrenia.

关 键 词：重复经颅磁刺激 精神分裂症 阴性症状 

分 类 号：R49[医药卫生—康复医学] R749.3[医药卫生—临床医学]