C_7N氨基环醇家族的天然α-糖苷酶/淀粉酶抑制剂研究进展  

Research Progress in Natural α-Glucosidase/Amylase Inhibitors Classified in the Family of C_7N Aminocyclitols

作　　者：耿鹏[1] 白钢[2] 

机构地区：[1]天津医科大学基础医学院,天津300070 [2]南开大学药学院,天津300071

出　　处：《天然产物研究与开发》2012年第6期848-855,共8页Natural Product Research and Development

基　　金：国家自然科学基金项目(30900015)

摘　　要：C7N氨基环醇家族化合物是一类由放线菌产生的天然化合物,化学结构相对较新颖。其核心基团井岗胺赋予该家族化合物多种生物活性,其中最主要的是α-糖苷酶/淀粉酶抑制剂活性。该家族化合物在生物医学和农业领域中具有较大的应用价值。本文将结合作者的研究方向,综述已被报道的C7N家族α-糖苷酶/淀粉酶抑制剂的化学结构与生物活性。The C7N aminocyclitol family is a relatively new class of natural products that is increasingly gaining recognition due to their significant biomedical and agricultural uses.These secondary metabolites are exclusively produced by microorganisms,particularly soil bacteria of the order of Actinomycetes.Their chemical structures most commonly contain an unsaturated aminocyclitol moiety,valienamine,which is known to be responsible for their biological activities.Among the C7N aminocyclitol family,most members act as α-glucosidase/amylase inhibitors.This review covers the discovery,structure determinations,and biological properties of α-glucosidase/amylase inhibitors classified in the family of C7N aminocyclitols,including the researches performed by the author of this article.

关 键 词：C7N氨基环醇 α-糖苷酶/淀粉酶抑制剂 放线菌 

分 类 号：TQ464.4[化学工程—制药化工]