电学因素和供应室pH对盐酸环丙沙星离子导入的影响  

Effects of Electrical Factors and pH of Donor Chamber Solution on Transdermal Iontophoresis of Ciprofloxacin

作　　者：童郁韫 应晓英[2] 

机构地区：[1]浙江省永康市第一人民医院,浙江永康321300 [2]浙江大学药学院,杭州310058

出　　处：《中国药学杂志》2012年第13期1056-1059,共4页Chinese Pharmaceutical Journal

基　　金：浙江省医学会临床科研基金资助项目(2009ZYC47)

摘　　要：目的研究电流、电压和供应室溶液的pH值对盐酸环丙沙星离子导入渗透速率的影响。方法以盐酸环丙沙星为模型药物,采用Valia-chien双室扩散池,分别测定不同电流强度、不同电压强度及不同pH溶液的离子导入渗透速率和增渗倍数。结果盐酸环丙沙星离子导入渗透速率和增渗倍数随着电流强度的增加而增加;当电流强度恒定,盐酸环丙沙星的离子导入增渗倍数随着电压强度的增加而增加;供应室溶液的pH值对离子导入透皮渗透有影响,当pH 3.5时,促渗效果较好。结论电学因素及供应室溶液的pH值是影响盐酸环丙沙星离子导入渗透速率的重要因素。OBJECTIVE To investigate the effects of current, voltage and pH of donor chamber solution on the iontophoretic transport of ciprofloxacin. METHODS An in vitro study was carried out to determine the iontophoretic permeability of ciprofloxacin through pig skin. lontophoretic flux of ciprofloxacin through excised pig skin was determined using Valia-Chien two chamber diffusion cells. The permeability enhancement ratios in donor chamber solution of different pH under different currents and voltages were also measured. RESULTS Iontophoretic flux of ciprofloxacin increased with increasing current and vohage. The effect of ciprofloxacin solu- tion pH in the donor chamber on the iontophoretic transport was observed. When the pH of ciprofloxacin solution was 3.5, there was good iontophoretic permeability. CONCLUSION The results suggest that electrical factor and pH of the donor chamber solution may be important factors for the iontophoretic permeability of ciprofloxacin.

关 键 词：环丙沙星 离子导入 PH 增渗倍数 电学因素 

分 类 号：R944[医药卫生—药剂学]