Human leukocyte antigen E in human cytomegalovirus infection： friend or foe？  

作　　者：Fang Gong Shengli Song Guozhong Lv Yuhong Pan Dongqing Zhang Hong Jiang 

机构地区：[1]Department of Laboratory medicine,The Third Hospital Affiliated to Nantong University,Wuxi 214041,China [2]Department of Immunology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [3]Department of Microbial Pathogenesis,The Third Hospital Affiliated to Nantong University,Wuxi 214041,China

出　　处：《Acta Biochimica et Biophysica Sinica》2012年第7期551-554,共4页生物化学与生物物理学报（英文版）

摘　　要：Human cytomegalovirus （HCMV） is a well-studied [3-her- pesvirus virus, which adopts a variety of strategies to evade immune surveillance. It has been reported that in HCMV-infected cells, classical major histocompatibility （MHC） class I molecules are down-regulated, but the MHC class Ib molecule human leukocyte antigen （HLA）- E is normally expressed or even overexpressed on the cell surface. HLA-E has been first described to interact with CD94/NKG2 receptors expressed mainly on the surface of natural killer （NK） cells, thus confining its role to the regulation of NK-cell function. The engagement of CD94/ NKG2A with HLA-E, with a signal peptide of the HCMV glycoprotein UL40, usually induces inhibitory signals. However, HLA-E also serves as a ligand for the TCR expressed by oLI^CD8＋ T cells. Recognition of peptides presented by HLA-E may result in CD8＋ effector T-cell activation. These findings will help to understand more on both pathogenic and protective roles of HLA-E in HCMV infection. In this review, we discussed recent studies about the roles of HLA-E in HCMV infection.Human cytomegalovirus （HCMV） is a well-studied [3-her- pesvirus virus, which adopts a variety of strategies to evade immune surveillance. It has been reported that in HCMV-infected cells, classical major histocompatibility （MHC） class I molecules are down-regulated, but the MHC class Ib molecule human leukocyte antigen （HLA）- E is normally expressed or even overexpressed on the cell surface. HLA-E has been first described to interact with CD94/NKG2 receptors expressed mainly on the surface of natural killer （NK） cells, thus confining its role to the regulation of NK-cell function. The engagement of CD94/ NKG2A with HLA-E, with a signal peptide of the HCMV glycoprotein UL40, usually induces inhibitory signals. However, HLA-E also serves as a ligand for the TCR expressed by oLI^CD8＋ T cells. Recognition of peptides presented by HLA-E may result in CD8＋ effector T-cell activation. These findings will help to understand more on both pathogenic and protective roles of HLA-E in HCMV infection. In this review, we discussed recent studies about the roles of HLA-E in HCMV infection.

关 键 词：major histocompatibility Ib humanleukocyte antigen-E CYTOMEGALOVIRUS 

分 类 号：Q347[生物学—遗传学] Q78