不同性别IgA肾病患者合并高尿酸血症的临床研究  

Clinical Research of IgA Nephropathy Associated with Hyperuricemia in Different Gender

作　　者：蒋易容[1] 文集[1] 张程珑[1] 樊均明[1,2] 

机构地区：[1]四川大学华西医院肾脏内科,成都610041 [2]泸州医学院附属医院肾脏内科

出　　处：《华西医学》2012年第6期833-836,共4页West China Medical Journal

基　　金：四川省青年科技基金项目(2011JTD0014)~~

摘　　要：目的探讨不同性别IgA肾病患者合并高尿酸血症的临床及肾脏病理特点。方法采用回顾性研究方法,将2008年1月-2010年12月收治的226例经肾活检确诊的原发性IgA肾病患者分为男性高尿酸血症组、男性尿酸正常组、女性高尿酸血症组及女性尿酸正常组4组,统计分析4组的临床指标及病理指标。结果高尿酸血症患病率男性(21.7%)高于女性(11.9%),差异有统计学意义(P<0.01),尿检异常型患病率男性(14.6%)高于女性(4.0%),差异有统计学意义(P<0.01),女性LeeⅢ级的患病率(7.1%)高于男性(5.8%),差异有统计学意义(P<0.01);男性高尿酸血症组的尿素氮高于尿酸正常组(P<0.05),女性高尿酸血症组的血尿素氮、血肌酐、胱抑素C、舒张压、甘油三酯比尿酸正常者明显增高(P<0.01),女性高尿酸血症组的高密度脂蛋白明显高于男性组(P<0.01)。结论高尿酸血症是IgA肾病的危险因素,可导致更严重的肾功能损害及肾脏病理损害,这种影响在不同性别中存在差异。Objective To investigate the clinical and pathological features of IgA nephropathy associated hyperuricemia in different gender. Methods We retrospectively reviewed the clinical data of 226 patients with biopsy- proved primary IgA nephropathy from January 2008 to December 2010. The patients were divided into male hyperuricemia group, male normouricemia group, female hyperuricemia group and female normouricemia group; then we analyzed and compared the clinical and pathological features among the groups. Results Prevalence of hyperuricemia in the males was higher than that in the females （21.7%, 11.9%; P 〈 0.01）, the same as the prevalence of asymptomatic abnormal urinalysis clinical type （14.6%, 4.0%; P 〈 0.01）. Prevalence of Lee Ill grade in female patients was higher than that in male patients （7.1%, 5.8%; P 〈 0.01） . Blood urea nitrogen （BUN） in male hyperuricemia group was higher than that in male normouricemia group （P 〈 0.05） . BUN, serum creatinine, cystatin C, diastolic blood pressure and triglyceride in female hyperuricemia group were significantly higher than those in female normouricemia group （P 〈 0.01） . High density lipoprotein in female hyperuricemia group was significantly higher than that in male group （P 〈 0.01） . Conclusion As causing more serious impaired renal functional and pathological damage, hyperufieemia is a risk factor of IgA nephropathy and has different effect in different gender.

关 键 词：IGA肾病 高尿酸血症 性别 

分 类 号：R692.3[医药卫生—泌尿科学] R589[医药卫生—外科学]