供浆者多次献浆后sdLDL-C和ox-LDL水平的测定  

Measurement of levels of sdLDL-C and ox-LDL in plasma of donors for long-term intensive plasmapheresis

作　　者：胡军[1] 何彦林[1] 刘学平[1] 杨鸿雁[1] 潘孟姣[1] 

机构地区：[1]兰州生物制品研究所有限责任公司,730046

出　　处：《微生物学免疫学进展》2012年第3期43-46,共4页Progress In Microbiology and Immunology

基　　金：国药中生课题(CNBG-LZ-044)

摘　　要：目的探讨多次献浆后,对供浆者体内血浆小而密低密度脂蛋白胆固醇(sdLDL-C)、氧化低密度脂蛋白(ox-LDL)水平变化的影响。方法分别检测100例多次献血浆者和100例初次献血浆者的血浆sdLDL-C和ox-LDL水平,同时检测其血脂及血浆蛋白水平。结果多次献血浆者的血浆sdLDL-C、ox-LDL以及血脂水平略有下降,但与初次献浆者之间无显著性差异;多次献血浆者的血浆总蛋白(TP)、白蛋白(ALB)与初次献浆者的水平相当,两者之间也无显著性差异。结论多次献血浆是安全的,不会增加动脉粥样硬化性心血管疾病的风险。Objective To investigate the changes of small dense low density lipoprotein cholesterol （ sdLDL-C ） and oxi- dized low density lipoprotein （ ox-LDL ） levels in plasma of donors after long-term intensive plasmapheresis. Methods sdLDL-C and ox-LDL levels in plasma were determined in 100 donors for intensive plasmapheresis and 100 blood donors for a initial plasmapheresis, respectively, and the levels of lipid and protein in plasma were also measured. Results No sig- nificant changes in levels of sdLDL-C, ox-LDL, plasma lipid and protein were observed in intensive plasmapheresis donors. Conclusion In this study the donors for long-term intensive plasmapheresis were safe, and it did not increase cardiovascu- lar risk in relation to atherosclerosis.

关 键 词：多次供浆者 小而密低密度脂蛋白(sdLDL-C) 氧化低密度脂蛋白(ox-LDL) 动脉粥样硬化 

分 类 号：R446.6[医药卫生—诊断学]