3.0T磁共振扩散张量成像对特发性癫痫的初步研究  

Diffusion tensor imaging with 3.0T magnetic resonance scanner in patients with idiopathic epilepsy

作　　者：刘群[1] 张体江[1] 张国明[1] 朱克文[1] 刘衡[1] 张高峰[1] 

机构地区：[1]遵义医学院附属医院放射科,贵州563003

出　　处：《放射学实践》2012年第7期718-721,共4页Radiologic Practice

基　　金：国家自然科学基金资助项目(30960099);贵州省科技厅基金资助项目[黔科合J字LKZ(2011)38号]

摘　　要：目的:利用磁共振扩散张量成像(DTI)探讨特发性癫痫患者脑微观结构的改变,分析其与临床变量的相关性。方法:21例特发性癫痫患者及21例年龄、性别及教育程度相匹配的健康人作为对照组参与本研究。所有受试者均为右利手。原始扫描图像首先经DTI Studio软件处理获得表观扩散系数(ADC)图、部分各向异性(FA)图。数据处理用SPM2软件进行基于体素的全脑分析,主要步骤有图像配准、标准化、平滑。统计分析采用两独立样本t检验。结果:病例组与对照组的年龄、性别及教育程度差异均无统计学意义(P>0.05)。特发性癫痫患者FA值减低区域位于右侧颞叶、岛叶、前扣带及小脑齿状核,ADC值升高区域位于右侧内囊前肢及外囊(P<0.05,成簇水平cluster>100)。相关分析发现右侧颞叶、额叶、枕叶及左侧内囊前肢的ADC值与病程呈正相关(P<0.05,成簇水平cluster>100)。结论:DTI检查能发现特发性癫痫患者脑微观病理改变,为特发性癫痫的病理生理机制研究提供了理论依据。Objective：To study the cerebral microstructure changes in patients with idiopathic epilepsy （IE） by diffusion tensor imaging （DTI） ,and to analyze the relation between DTI and clinical features. Methods：Twenty-one patients with IE and twenty-one cases with age, sex-, education level-matched healthy controls were enrolled in this study. All were rightlaterality. DTI scanning was performed with a 3.0T MR scanner. DTI data were calculated using DTI-studio for each subject,including apparent diffusion coefficient （ADC） maps, fractional anisotropy （FA） maps. SPM2 software was used for whole-brain voxel-based analysis,the main steps of study included co-registeration, normalization and smoothing. Statistical analysis was made using two sample t-test, the differences of P〈0.05 would be considered as statistical significance. Re- suits.. No statistic differences were showed in age, sex and between the two groups （P〉0.05）. Compared with the controls, the FA values reduction areas in patients with IE were assessed in right temporal lobe,right insula,right anterior cingulate and right cerebellar dentate nuclei;ADC values increased in right anterior limb of the internal capsule and the right external capsule （P〈0.05, cluster level 〉100）. The ADC values of right temporal lobe, frontal lobe,occipital lobe and left anterior limb of internal capsule were positively correlated with the duration of illness （P〈0.05, cluster level 〉100）. Conclusion： Subtle neuropathological changes in patients with idiopathic epilepsy could be detected on DTI,which provides a theoretical basis for pathophysiology study of idiopathic epilepsy.

关 键 词：癫痫 磁共振成像 扩散张量成像 基于体素分析 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.1[医药卫生—诊断学]