牛黄解毒丸红外指纹图谱间相似度的定量分析  

Quantitative Analysis of Similarity between IR Fingerprint Spectra of Niuhuang Jiedu Pilulae

作　　者：庞涛涛[1] 杜黎明[1] 

机构地区：[1]山西师范大学分析测试中心,山西临汾041004

出　　处：《山西师范大学学报（自然科学版）》2012年第2期55-59,共5页Journal of Shanxi Normal University(Natural Science Edition)

基　　金：山西省自然科学基金资助项目(2007011027)

摘　　要：以不同厂家和同一厂家不同批号的牛黄解毒丸为研究对象,制备它们的粉末样品并做出傅立叶变换红外指纹图谱(FTIR).直接从中药指纹图谱的检测数据出发,采用相关系数、夹角余弦和距离系数对任意两张图谱间的相似度进行量化评价和比较.结果表明:红外图谱的相似度分析结果与实际情况相符.本文提出的方法可很好地反映红外图谱之间的相似程度,进一步完善后可用于其他类型的图谱分析.Taking Niuhuang Jiedu Pilulae from different manufacturers and different batch numbers （same factory） as research objects, Fourier transform Infrared （FFIR） absorption spectra of powder were obtained. On the basis of detection data of traditional Chinese drug fingerprints, quantitative commentary and eomparision were carried out on the similarity of two spectra with three indices-coefficient of correlation, included angle cosine and coefficient of distance. The analysis result of IR spectra of Niuhuang Jiedu Pilulae was accordant with that of the experiments. The method supplied in this paper can satisfactorily reflect the similarity of different IR spectra, as well as other kind spectra with further implementation.

关 键 词：牛黄解毒丸 指纹图谱分析 相似度 中药 

分 类 号：O657.33[理学—分析化学]