分裂症患者血清白细胞介素水平的分析研究  

Analysis and research on the serum interleukin levels in schizophrenia patients

作　　者：黄肖峰[1] 吴琦珀[1] 陈元林[2] 庄华琴[1] 

机构地区：[1]福建省泉州市第三医院检验科,362000 [2]福建省泉州市第三医院精神科,362000

出　　处：《检验医学与临床》2012年第13期1550-1551,1553,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨首发分裂症患者治疗前后血清中白细胞介素-2(IL-2)和IL-6浓度水平变化。方法对79例首发分裂症患者治疗前及治疗后第6周末采用双抗体夹心酶联免疫吸附法检测血清中IL-2和IL-6浓度水平,同时用PANSS评定精神症状,以41例健康者为对照组。结果患者治疗前血清中的IL-2和IL-6浓度水平分别为(849±163)pg/L、(1 335±252)pg/L,明显高于对照组,分别为(539±101)pg/L、(992±151)pg/L,P<0.01;患者治疗前血清中的IL-2和IL-6浓度水平呈显著正相关(r=0.330,P=0.003);患者治疗后血清中的IL-2浓度水平(572±120)pg/L和治疗后的PANSS总分(40.53±11.07)分呈显著负相关(r=-0.304,P=0.006)。结论首发分裂症患者存在细胞免疫异常,治疗前血清中的IL-2和IL-6浓度水平升高且呈显著正相关。Objective To explore the change of the serum interleukin-2（IL-2） and interleukin-6（IL-6） in the first-episode schizophrenia patients before and after treatment.Methods We used enzyme-linked immunosorbent assay（ELISA） to test the serum levels of IL-2 and IL-6 in 79 first-episode schizophrenia patients and 41 control subjects before treatment and at the end of 6 weeks treatment.At the same time the PANSS were compared between groups and correlations were determined.Results The serum IL-2 and IL-6 of patients[（849±163）pg/L,（1 335±252）pg/L] were significant higher than control subjects[（539±101）pg/L,（992±151）pg/L,P〈0.01];there was a significant positive relationship between the serum IL-2 and IL-6 levels before treatment（r=0.330,P=0.003）;there was a significant negative relationship between the serum IL-2[（572±120）pg/L] and the PANSS[（40.53±11.07）points] after treatment（r=-0.304,P=0.006）.Conclusion The first-episode schizophrenia patients have cellular immune abnormality.The serum IL-2 and IL-6 levels rise before treatment.There is a significant positive relationship between the serum IL-2 and IL-6 levels before treatment.

关 键 词：分裂症 白细胞介素 酶联免疫吸附法 

分 类 号：R692.5[医药卫生—泌尿科学]