肾血流彩色多普勒检测与骨形态发生蛋白-7检测在2型糖尿病肾病早期诊断中的价值  

Evaluation of color Doppler ultrasound of renal blood flow combined with the detection of bone morphogeneticprotein-7 in early diagnosis of type 2 diabetic nephropathy

作　　者：张之杰[1] 于宁[1] 王正滨[1] 闫志梅[1] 孟冬梅[1] 刘荣桂[1] 丁兆艳[1] 史锋锋[1] 

机构地区：[1]青岛大学医学院附属医院超声诊断中心,266003

出　　处：《中华超声影像学杂志》2012年第7期591-594,共4页Chinese Journal of Ultrasonography

摘　　要：目的探讨彩色多普勒超声检查肾血流与骨形态发生蛋白-7（BMP-7）水平检测在2型糖尿病肾病中的诊断价值。方法检测90例糖尿病肾病患者与30例健康志愿者血BMP-7水平，并经彩色多普勒超声测量肾血流动力学参数，比较各组血BMP-7水平、肾段动脉及肾叶间动脉阻力指数（RI）。结果与对照组比较，随着糖尿病肾损害程度加重，BMP-7水平逐渐降低（P〈0．01），肾段动脉、肾叶间动脉收缩期最大血流速度及舒张末期最低血流速度逐渐减慢，RI增高（P〈0．01）。BMP-7水平与肾段动脉、叶间动脉RI间存在显著负相关（r=-0．603，P〈O．01；r=-0．652，P〈0．01）。结论彩色多普勒超声测量肾血流动力学参数联合检测血BMP-7水平对早期预测糖尿病肾病的肾损害程度有重要价值。Objective To evaluate the significance of color Doppler ultrasound examination of renal blood flow combined with the detection of bone morphogenetic protein-7（BMP-7） in early diagnosis of type 2 diabetic nephropathy. Methods Blood BMP-7 level was tested in 90 patients with type 2 diabetic nephropathy and 30 controls, and parameters of renal blood flow were measured by color Doppler ultrasound examination. Blood BMP-7 level as well as resistant index （RI） of segmental renal artery （SRA） and interlobar renal artery（IRA） ,were compared between these two groups. Results Compared with controls, blood BMP-7 level gradually decreased with the aggravation of diabetic kidney damage（ P d0. 01）. The peak systolic velocity （Vmax） and the end diastolic velocity （Vmin） of SRA and TRA were slowed gradually, while RI increased（ P 〈0.01）. Blood BMP-7 level was negatively correlated with IRA＇s and SRA＇s RI of IRA and SRA（r = -0.603, P〈0.01; r = -0.652, P 〈0.01）.Conelusions Color Doppler ultrasound examination of renal blood flow combined with detection of BMP-7 might play an important role in early diagnosis of type 2 diabetic nephropathy.

关 键 词：超声检查 多普勒 彩色 糖尿病肾病 肾 血液动力学现象 骨形态发生蛋白质类 

分 类 号：R445.1[医药卫生—影像医学与核医学] R587.2[医药卫生—诊断学]