时间-空间相关成像技术定量评价胎儿左心室容积的研究  

Evaluation of fetal left ventricular volume with spatiotemporal image correlation（STIC）

作　　者：张云姣[1,2] 赵博文[1,2] 潘美[1,2] 杨园[1,2] 黎鹏[1,2] 唐海林[1,2] 徐海珊[1,2] 王蓓[1,2] 

机构地区：[1]浙江大学医学院附属邵逸夫医院超声科,杭州310016 [2]浙江大学邵逸夫临床医学研究所

出　　处：《中华超声影像学杂志》2012年第7期598-602,共5页Chinese Journal of Ultrasonography

基　　金：资助项目：浙江省自然科学基金项目（Y2080080）

摘　　要：目的探讨时间一空间相关成像技术（spatiotem poralimagecorrelation，STIC）在定量胎儿左心室容积中的价值。方法通过三维容积探头获得162例孕龄22-38周胎儿的心脏三维数据，应用STIC对容积数据处理并获得胎儿心脏形态结构评估要求的多个切面。通过VOCALII功能进行左室三维重建，对胎儿左室功能进行评估，获得左室舒张末期容积（EDV）、收缩末期容积（EsV），并与M型Teichholz法、二维超声心动图简化Simpson法测定的结果进行比较。结果剔除图像质量较差的26例、双胎2例，共有134例正常胎儿纳入分析，三种方法两两比较，STICVOCALII法与二维超声心动图简化Simpson法所测EDV、ESV相关性最好，r分别为0．968和0．956，Bland—Altman分析两者一致性最好，存在最小偏倚，EDV为0．282ml、ESV为0．117ml。采用Bland—Altman分析三种测量方法，STICVOCALⅡ法的重复性最好，观察者间EDV的偏倚为0．190ml，ESV的偏倚为0．028ml；观察者内EDV的偏倚为0．076ml，ESV的偏倚为0．053ml。M型Teichholz法与STICVOCALⅡ法、2DESimpson法所测得左室容积比较差异均有统计学意义，STICVOCALⅡ法与2DESimpson法所测左室容积比较差异无统计学意义。结论S口ICVOCALII法和二维超声心动图简化Simpson法测量左室容积有良好的一致性，且STICVOCALII法所测左室容积观察者间及观察者内重复性均较其他两种方法好。STIC能够更准确地定量正常胎儿的左室容积，三维重建更合理准确地评估心室收缩功能，有助于深入了解发育中的胎儿心脏结构和功能。Objective To investigate the feasibility of assess left ventricular volume in normal fetuses. Methods spatiotemporal image correlation （STIC） to The volume data acquisition of 162 normal fetuses ranging between 22 and 38 weeks of gestation was achieved by automatic sweep scan. The virtual organ computer-aided analysis （VOCAL II ） was then used to evaluate end-systolic and end-diastolic volumes of left ventricle and compared with that obtained by M-mode Teichholz formula and 2D biplane Simpson＇s method. Results Twenty-six fetuses with poor STIC image and 2 twin pregnancies were excluded,the study subjects consisted of 134 singleton fetuses. The highest concordance correlation （ r = 0. 968,for EDV, r = 0. 956 for ESV; P = 0. 000） was noted between 2D biplane Simpson＇ s and STIC VOCAL Ⅱ values with a small bias （0. 282 ml for EDV,0. 117 ml for ESV）. The Bland-Airman analysis showed that STIC VOCAL Ⅱhad the best agreement than M-mode Teichholz formula and 2D biplane Simpson＇s method. The result showed that there were significant difference between M-mode Teichholz formula and Simpson＇s method in EDV and ESV （ P 〈0.05）. There were significant differences between M-mode Teichholz formula and STIC VOCAL Ⅱ （P 〈 0.05）. There were no significant differences between STIC VOCAL Ⅱ and Simpson＇ s method in EDV and ESV. Conclusions There is a goodagreement between left ventricular volumes measured either by STIC VOCAL Ⅱ or by 2D biplane Simpson＇s method. STIC is a novel technique that can be more accurate than conventional methods in quantification of fetal left ventrieular volumes. All the volume data acquisition is achieved by postprocessing facilities. STIC promises to become a new method for left ventricular volume quantification.

关 键 词：超声心动描记术 胎儿 心室功能 左 心室容积 左 时间一空间相关成像 

分 类 号：R445.1[医药卫生—影像医学与核医学]