复方口服避孕药对糖代谢和脂代谢的影响  

Influence of Combination Oral Contraceptives on Carbohydrates and Lipids Metabolism

作　　者：王巍[1] 王蔼明[1] 姜文[1] 贾晓宁[1] 

机构地区：[1]海军总医院妇产科,北京100048

出　　处：《生殖与避孕》2012年第7期470-477,共8页Reproduction and Contraception

摘　　要：复方口服避孕药可以影响一系列代谢因素的改变,如糖代谢和脂代谢相关指标。雌、孕激素对代谢的影响因其剂量和种类而异。雌激素剂量越低对代谢的影响越小;孕激素对代谢的影响与其雄激素样特性有关,非雄激素样或抗雄激素样特性的孕激素对糖代谢和脂代谢影响最小。本文分别就不同类型口服避孕药、不同给药途径和不同给药方式对糖代谢和脂代谢的影响,以及在避孕药的特殊使用人群多囊卵巢综合征患者中糖代谢和脂代谢的变化加以综述,使我们能够对避孕药有更加准确和客观的认识。Combination oral contraceptives （COCs） should affect a series of metabolic factors, such as carbohydrates and lipids profile. The metabolic effects of the COCs seem to be related to their types and dose. The lower doses of estrogen influence the metabolism smaller. The metabolic effects of the progestins seem to be related to their androgenic properties. Non-androgenic or anti-androgenic progestins exert minimal influence on the lipid profile and carbohydrate metabolism. The carbohydrates and lipids metabolic effects of different kinds of COCs, different routes of delivery, and different methods of administration are discussed in this article. The metabolic effect of oral contraceptives on women with PCOS are discussed at the same time. This review are expected to reinforce the benefits and the risks of COCs.

关 键 词：复方口服避孕药(COCs) 糖代谢 脂代谢 多囊卵巢综合征(PCOS) 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]