颈管细胞及化生细胞在宫颈液基细胞学检查中的临床价值  

Clinical Value of Endocervical Cells and Metaplastic Cells by Liquid-based Cytology Technique

作　　者：陈枝岚[1,2] 黄科程[1] 胡婷[1] 杨茹[1] 李雄[1] 张庆华[1,3] 贾瑶[1] 沈健[3] 王少帅[1] 唐方徐[1] 周航[1] 马丁[1] 王世宣[1] 李双[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇科肿瘤实验室,武汉430030 [2]广州军区武汉总医院妇产科,武汉430070 [3]武汉市中心医院妇产科,武汉430014

出　　处：《华中科技大学学报（医学版）》2012年第3期320-323,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家重点基础发展计划("973"计划)(No.2009CB521808);卫生公益性行业科研专项基金(No.201002013);国家自然科学基金(No.81101964;30973472;81001151;81071663;30973205;30973184)资助项目

摘　　要：目的探讨颈管细胞(EC)和化生细胞(MSC)在宫颈病变筛查中的临床价值。方法将28 952份液基细胞学标本按颈管细胞和化生细胞存在状态分为EC(+)/MSC(+)、EC(+)or MSC(+)及EC(-)/MSC(-)等3组,比较各组液基标本的满意率和细胞学异常的检出率。结果细胞学异常总检出率为3.54%,其中低级别上皮内瘤变(LSIL)、高级别上皮内瘤变(HSIL)及宫颈鳞癌(SCC)检出率分别为1.11%、0.36%、0.02%;细胞学异常总检出率在EC(+)/MSC(+)组最高(7.82%),其次是EC(+)or MSC(+)组(5.21%),EC(-)/MSC(-)组检出率最低(1.28%),差异具有统计学意义(P<0.01)。EC(+)/MSC(+)组液基标本满意率(细胞量>40%)达89.77%,EC(+)or MSC(+)组次之(77.67%),EC(-)/MSC(-)组为70.42%,差异有统计学意义(P<0.01)。结论液基细胞学检查标本中颈管细胞及化生细胞存在与否对液基标本质量和宫颈细胞学异常的总检出率有影响。Objective To investigate the clinical significance of endocervical cells（EC）and metaplastic squamous cells（MSC）in the screening of cervical cancer.Methods The screening results and the status of EC and MSC of 28 952 copies were statistically calculated to compare the satisfaction rate and the detection rate of abnormal cytology under different cellular components.Results The overall detection rate of abnormal cytology was 3.54%,and the coincidence rate of LSIL,HISL and SCC was 1.11%,0.36% and 0.02%,respectively.The detection rate was highest in EC（＋）/MSC（＋）group（7.82%）,followed by EC（＋）or MSC（＋）group（5.21%）,and the lowest detection rate（1.28%）was found in EC（-）/MSC（-）group（P0.01）.The satisfaction rate was highest in EC（＋）/MSC（＋）group（89.77%）,followed by EC（＋）or MSC（＋）group（77.67%）and EC（-）/MSC（-）group（70.42%）（P0.01）.Conclusion The status of EC and MSC affects the overall detection rate of abnormal cervical cytology.

关 键 词：液基薄层细胞学 颈管细胞 化生细胞 

分 类 号：R446.82[医药卫生—诊断学]