亚氨基吡格列酮的新合成方法研究  

The Study of Novel Synthetic Method of Imi pioglitazone

作　　者：徐建康 赵宗敏 蔡亚祥 蒋志强 陈滔 

机构地区：[1]浙江九洲药业股份有限公司,浙江台州318000

出　　处：《广州化工》2012年第12期107-108,共2页GuangZhou Chemical Industry

摘　　要：以4-(2-(5-乙基吡啶-2-基)乙氧基)苯甲醛为原料,通过还原、氯化、缩合、溴化、环合五步反应得到亚氨基吡格列酮,总收率57%。此方法原料易得,反应条件温和,操作过程简单,未使用毒性较大的丙烯酸甲酯,产品收率较高,有利于工业化生产。A novel synthetic method of 5-{4-[2-（5-Ethyl-2-pyridyl）ethoxy]benzyl}-2-imino-4-thiazolidin-one can be got through reduction chloration condensation bromination and cyclization when the 4-[2-（5-Ethyl-pyridin-2-yl）-ethoxy]-benzaldehyde was used as raw material.The total yield was achieved to 57%.Comparing to other ordinary methods.this synthetic route had many advantages,such as cheap raw materials,mild reaction conditions,simple opration,and higher yield,especially high toxic methyl acrylate was not used,so it had broad application prospects in industry production.

关 键 词：乙酰乙酸甲酯 溴化 亚氨基吡格列酮 

分 类 号：TQ463.53[化学工程—制药化工]