侧脑室注射氯胺酮降低成年SD大鼠海马区突触可塑性  

Effect of ketamine injected into cerebro ventriles on synaptic plasticity of hippocampus in adult SD rats

作　　者：郭东勇[1] 谭涛[2] 田心[2] 王国林[3] 

机构地区：[1]天津医科大学附属肿瘤医院麻醉科,天津市肿瘤防治重点实验室,天津300060 [2]天津医科大学生物医学工程学院,天津300070 [3]天津医科大学总医院麻醉科,天津300052

出　　处：《天津医科大学学报》2012年第2期189-191,共3页Journal of Tianjin Medical University

摘　　要：目的:研究侧脑室注射氯胺酮对成年SD大鼠在体海马区长时程增强(LTP)的影响。方法:成年SD大鼠12只,随机分为实验组(C-I组)和对照组(C组),前者经右侧脑室注射50μg氯胺酮(生理盐水稀释至5μL),后者注射等量生理盐水后,记录在体海马区LTP。结果:高频刺激后30 min时,C组和C-I组分别为条件刺激PS幅值的(216.29±12.11)%和(138.04±6.50)%(P<0.05);刺激后60 min时,分别为(202.33±11.53)%和(149.60±10.86)%(P<0.05),C-I组LTP突触可塑性改变程度较对照组显著降低。结论:侧脑室注射氯胺酮可显著降低成年大鼠海马区突触可塑性。Objective： To observe the effect of ketamine of intracerebroventricular injection to adult SD rats on LTP of hippocampus. Methods： 12 adult SD rats were randomly divided into group C and C-I. LTP was recorded after NS or ketamine（50 μg） 5μL, were inject- ed into cerebro ventriles respectively. Results： 30 rain after stimulation, PS amplitude in group C and C-I were （216.29±12.11）% and （138.04±6.50）% （P〈0.05）. 60 rain after stimulation, PS amplitude were （202.33±11.53）% and （149.60±10.86）%（P〈0.05）. LTP in greup C-1 reduced obviously. Conclusion： Ketamine of intracerebroventricular injection reduces synaptic plasticity ofhippocampus in adult SD rats.

关 键 词：氯胺酮 侧脑室 海马区 长时程增强 大鼠 

分 类 号：R614.1[医药卫生—麻醉学]