黄酮类金属配合物的生物活性研究进展  

Advance of studies on bioactivity of flavonoid-metal complexes

作　　者：刘衍季[1] 何小燕[1] 左华[1] 张齐雄[1] 李逐波[1] 施伦勇[1] 

机构地区：[1]西南大学药学院,重庆400716

出　　处：《中国中药杂志》2012年第13期1901-1904,共4页China Journal of Chinese Materia Medica

基　　金：重庆市科技攻关项目(CSTC;2008AA1001)

摘　　要：中药的黄酮类成分与金属离子形成配合物后,其抗菌、抗病毒、抗炎、抗肿瘤、降血糖、抗溃疡和抗自由基等生物活性会显著增强,原因可能是配合物形成后结构发生改变而使其更易接近靶点产生更强的结合力,或是发挥黄酮类中药活性成分与金属离子的协同作用。该文就黄酮类金属配合物的生物活性及其作用机制研究进行综述,旨在为黄酮类中药有效成分的深入研究及开发提供参考。The flavonoid-metal complexes showed obviously stronger bioactivities such as antibiosis, antivirus, anti-inflamma- tory, anti-tumor and anti-free-radical, possibly because of the stronger binding force caused by the change in complex structure and ac- cessibility to target spots, or the synergy effect between flavonoids and metallic ions. This essay summarizes studies on bioactivity and mechanism of flavonoid-metal complexes, in order to provide reference for in-depth study and development on effective constituents con- tained in flavonoid traditional Chinese medicines.

关 键 词：黄酮类 配合物 生物活性 作用机制 

分 类 号：R285.5[医药卫生—中药学]