基于益气固脱功效的人参药材质量评价的探讨  

Study on quality evaluation of Panax ginseng based on effects for replenishing Qi and preventing exhaustion

作　　者：王立岩[1] 田义新[1] 李海涛[2] 王丽[1] 吕晓军[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118 [2]长春中医药大学附属医院,吉林长春130021

出　　处：《中国中药杂志》2012年第13期2030-2033,共4页China Journal of Chinese Materia Medica

基　　金：吉林省教育厅"十二五"科学技术研究项目

摘　　要：作者提出从益气固脱的功效入手,重建人参质量评价体系;中医药固然是独立的医学体系,但这不应成为因拿不出可信证据给自己辩解的理由。因此,相关的中医药科研亟待加强。现在的中药实验研究的一个误区是从西医学角度出发,对药物进行的验证性研究,针对"唯成分论"和"唯技术论"作者提出以下研究模式:以中医药理论为指导,建立符合中医临床的中药质量评价新模式———临床功效→药理作用→功效组分,在功效组分的层面上进行化学指纹图谱或有效成分的研究。重新建立中药质量评价体系的观点值得深入研究。作者在分析历代本草文献和中医临床用药经验的基础上,得出人参(独参汤)无药可代的功效为"益气固脱"。从人参的这个主要功效入手,结合现代临床主治,建立药理模型,筛选人参药材的功效组分,对人参临床用药的安全性和有效性进行质量评价,为长白山人参资源的栽培、开发和利用提供理论和实验依据。Based on the effect for replenishing Qi and preventing exhaustion, this essay provides a method to rebuild the quali- ty evaluation system of Panax ginseng. As an independent medical system, the traditional Chinese medicine （TCM） science lacks enough credible evidences to support its theory and thereby wants more relevant studies. Current, it is a misunderstanding for experi- mental studies on TCM to prove TCM drugs from the angle of western medicine. Therefore, following study modes are recommended to researchers focusing on either the theory of the unique importance of class origin or the theory of the unique importance of techniques. Under the guidance of TCM theories, a new TCM assessment mode, consisting of clinical efficacy, pharmacological effect and effective components, is established in line with clinical application of TCMs. Studies on Chemical fingerprint or active ingredient are made on effective components. In-depth studies are worth to the viewpoint to rebuild the TCM quality reassessment system. On the basis of anal- ysis on ancient herbal literatures and experience in clinical application of TCMs, the author proves the irreplaceable effect of P. gin- seng. （pure ginseng decoction） is to replenish Qi and prevent exhaustion. Based on the major effect, a pharmacological model is estab- lished in combination with modern clinical efficacy to screen effective components of ginseng herbs and make a quality assessment on safety and efficiency of clinical application of P. ginseng, in order to provide theoretical and experimental basis for cultivation, devel- opment and utilization of P. ginseng resources on changbai mountain.

关 键 词：人参 独参汤 益气固脱 功效组分 质量评价 

分 类 号：R284[医药卫生—中药学]