决奈达隆有关物质的合成  

Synthesis of Related Substance of Dronedarone

作　　者：刘玉丽[1] 汪玉梅 胡永亮 李晓康[1] 张勇[1] 

机构地区：[1]河北科技大学化学与制药工程学院,河北石家庄050018 [2]石药集团有限公司,河北石家庄050035

出　　处：《中国医药工业杂志》2012年第7期535-538,共4页Chinese Journal of Pharmaceuticals

基　　金：国家"重大新药创制"科技重大专项资助(2011ZX09202)

摘　　要：2-丁基-5-硝基苯并呋喃和4-甲氧基苯甲酰氯经Friedel-Crafts反应、去甲基化、醚化、还原和甲磺酰化制得N-[2-丁基-3-[4-(3-氯丙氧基)苯甲酰基]-5-苯并呋喃基]甲磺酰胺,再经碘代后与正丁胺反应得到去丁基决奈达隆,结构经核磁共振氢谱、碳谱、红外光谱和质谱确证,该化合物可作为决奈达隆质控的对照物。Debutyldronedarone, the related substance in the quality control of dronedarone, was synthesized by Friedel-Crafts reaction from 2-butyl-5-nitrobenzofuran and 4-methoxybenzoyl chloride, followed by demethylation, etherification, reduction and mesylation to give N- [2-butyl-3- [4- （3-chloropropoxyl） benzoyl]benzofuran-5-y1] methyl sulfonamide, which was subjected to iodonation and amination with n-butylamine. The structure of the target compound was confirmed by ^1H NMR, ^（13）C NMR, IR and MS.

关 键 词：去丁基决奈达隆 决奈达隆 有关物质 合成 

分 类 号：R972.2[医药卫生—药品]