西罗莫司纳米脂质载体固化制剂的制备  

Preparation of Solidification Preparation of Sirolimus Nanostructured Lipid Carriers

作　　者：吴昊[1] 张晶[2] 宋洪涛[1,2] 

机构地区：[1]福建医科大学福总临床医学院,福建福州350004 [2]南京军区福州总医院药学科,福建福州350025

出　　处：《中国医药工业杂志》2012年第7期562-567,共6页Chinese Journal of Pharmaceuticals

基　　金：福建省自然科学基金(2010J01218)

摘　　要：采用冷冻干燥法以微晶纤维素Avicel PH-101与聚乙烯吡咯烷酮(PVP)K30的混合物(4:1,w,%)为吸附性粉末固化西罗莫司纳米脂质载体分散液,并以再分散时间、平均粒径及分布、流动性和泄漏率等为指标,采用单因素试验优化固化处方。结果表明,3批按优化方法制备的西罗莫司纳米脂质载体固化制剂的休止角为(42.65±0.80)。,振实密度为(0.79±0.03)g/m1,且含量均匀度良好,再分散时间为(10.0±0.4)min,再分散液粒径(132.7+2.6)nm,分布系数0.297±0.01,ξ电位(-12.8±1.05)mV,冻干前后的泄漏率为(10.80±0.41)%。ABSTRACT： The sirolimus nanostructured lipid carriers was solidified by freeze-drying method with the mixture of microcrystalline cellulose （Avicel PH-101） and polyvinyl pyrrolidone （PVP） K30 （4 ： 1, w/w） as the adsorption powder. The preparation was optimized by single factor test with dispersing time, average particle size and distribution, fluidity and leakage rate as the indexes. The results showed that the angle of repose and tap density of three batches of the optimized solidified powder were （42.65±0.80） ° and （0.79±0.03） g/ml with good content uniformity. The solidified powder could disperse within （10.0±0.4）min and the average particle size and polydispersity index （PDI） of its redispersing solution were （132.7±2.6）nm and 0.297±0.01 with the ζ potential of （-12.8±1.05）mV. The leakage rate of the products was （10.80±0.41） %.

关 键 词：纳米脂质载体固化制剂 西罗莫司 固化 吸附性粉末 冷冻干燥法 

分 类 号：R944.9[医药卫生—药剂学]