蔓性千斤拔根的化学成分研究  

Chemical constituents from roots of Flemingia philippinensis

作　　者：李丹毅[1] 富艳彬[1,2] 华会明[1,2] 李占林[1,2] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《中草药》2012年第7期1259-1262,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的研究蔓性千斤拔Flemingia philippinensis根的化学成分。方法采用多种色谱方法进行分离纯化,运用各种波谱学方法鉴定化合物的结构。结果从蔓性千斤拔乙醇提取物的正丁醇萃取物中分离得到6个化合物,分别鉴定为3,5,7,4′-四羟基-3′-甲氧基黄酮-6-C-β-D-吡喃葡萄糖苷(1)、山柰酚-6-C-β-D-吡喃葡萄糖苷(2)、染料木苷(3)、芒柄花苷(4)、印度黄檀苷(5)和3′-O-甲基-香豌豆酚-7-O-β-D-吡喃葡萄糖苷(6)。结论化合物1为新的黄酮醇碳苷类化合物,命名为千斤拔苷A,化合物2和4为首次从该属植物中分离得到。Objective To investigate the chemical constituents in the roots of Flemingia philippinensis. Methods Various chromatographic methods were employed to isolate the compounds and their structures were established by detailed spectroscopic analysis. Results Six compounds were isolated in the n-butanol fractiom of crude ethanol extract from E philippinensis and were identified as 3, 5, 7, 4＇-tetrahydroxy-3＇-methoxyflavone-6-C-β-D-glucopyranoside （1）, kaempferol-6-C-β-D-glucopyranoside （2）, genistin （3）, ononin （4）, sissotrin （5）, and 3＇-O-methylorobol-7-O-β-D-glucopyranoside （6）. Conclusion Compound 1 is a new flavonol C-glycoside named flemingoside A, and compounds 2 and 4 are firstly isolated from the plants in Flemingia Roxb.

关 键 词：蔓性千斤拔:千斤拔属 黄酮醇碳苷 千斤拔苷A 芒柄花苷 

分 类 号：R284.1[医药卫生—中药学]