培哚普利对慢性心力衰竭患者血清生长分化因子15水平的影响  

Effect of perindopril on serum GDF-15 level in chronic heart failure patients

作　　者：邬江涛[1] 何燕[1] 钟国强[1] 李醒三[1] 闭奇[1] 吴龙飞[1] 

机构地区：[1]广西医科大学第一附属医院老年心内科,南宁530021

出　　处：《中华老年心脑血管病杂志》2012年第7期711-714,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：广西壮族自治区教育厅科研项目(201106LX091)

摘　　要：目的研究培哚普利对慢性心力衰竭(心衰)患者血清生长分化因子15(GDF-15)水平的影响及与病情的相关性。方法将79例慢性心衰(心衰组)患者随机再分为2组:小剂量组39例,大剂量组40例,疗程6个月。另选择40例仅有心血管病危险因素的患者作为对照组。ELISA法检测2组治疗前后GDF-15、N末端B型钠尿肽前体(NT-proBNP)水平;分析GDF-15与NT-proBNP、纽约心功能分级(NYHA)、超声心动图指标的相关性。结果心衰组GDF-15、NT-proBNP水平明显高于对照组(P<0.01)。NYHAⅠ～Ⅳ级患者GDF-15、NT-proBNP水平随NYHA逐级递增(P<0.01)。GDF-15分别与NT-proBNP(r=0.903,P=0.000)、NYHA(r=0.636,P=0.000)、左心室舒张末内经(r=0.806,P=0.000)呈正相关,与LVEF(r=-0.704,P=0.000)呈负相关。治疗6个月后,小剂量组与大剂量组GDF-15、NT-proBNP水平较治疗前明显降低(P<0.01),大剂量组较小剂量组降低更明显(P<0.01)。结论 GDF-15可作为新的心衰标记物,有助于评估疗效和预后。Objective To study the correlation between the effect of perindopril on serum GDF-15 level in chronic heart failure（CHF） patients and the condition of CHF patients. Methods Seven- ty-nine CHF patients were randomly divided into low perindopril（LP） group（n： 39） and high perindopril（HP） group（n： 40）, and 40 patients with risk factors for cardiovascular disease served as a control group. Patients in LP group received perindopril（4 mg/d） plus routine anti-hear fail- ure treatment and those in HP group received perindopril（8--10 rag/d） plus routine anti-heart failure treatment for 6 months. Their serum GDF-15 and NT-proBNP levels were measured by ELISA before and after treatment. Correlation of GDF-15 level with NT-proBNP, NYHA classifi- cation and echocardiographic parameters was analyzed. Results The GDF-15 and NT-proBNP levels were significantly higher in heart failure group than in control group and increased with the NYHA classification in related with NT-proBNP（ negatively related ly lower in LP and HP than before treatment（ failure and contributes of CHF patients. -- IV NYHA CHF patients（P%0.01）. The GDF-15 level was positively r= 0. 903）,NYHA classification（r= 0. 636）, LVEDD（r= 0. 806） mad LVEF（r= - 0. 704）. The GDF-15 and NT-proBNP levels were significant- groups, especially in HP group than in LP group, 6 months after treatment P〈0.01）. Conclusion GDF-15 can be used as a novel marker for heart to the assessment of the therapeutic effect of perindopril and the prognosis

关 键 词：培哚普利 心力衰竭 利钠肽 脑 超声心动描记术 

分 类 号：R541.6[医药卫生—心血管疾病]