红细胞山梨醇水平与糖尿病患者糖代谢控制  

ERYTHROCYTE SORBITOL LEVELS ARE RELATED TO THE CONTROL OF CARBOHYDRATE METABOLISM IN DIABETES MELLITUS

作　　者：王洪[1] 陈家伟[1] 张忠邦[1] 蒋须勤[1] 

机构地区：[1]南京医学院第一附属医院内分泌科

出　　处：《中华内分泌代谢杂志》1990年第1期11-13,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：采用山梨醇脱氢酶法测定了正常人23例及糖尿病66例的红细胞山梨醇水平。发现血糖控制差的Ⅰ型及Ⅱ型糖尿病的红细胞山梨醇水平显著高于正常对照组,且与同时测定的空腹血糖、24小时尿糖以及HbAic之间存在着显著的正相关;血糖控制好的Ⅱ型糖尿病组的红细胞山梨醇水平与正常对照组无显著差异且与空腹血糖不相关;血糖控制差的Ⅰ型与Ⅱ型糖尿病组之间空腹血糖差异无显著性,但红细胞山梨醇水平差异却有显著性。提示红细胞山梨醇水平可以作为糖尿病患者糖代谢控制好坏的一个指标。The red blood cell sorbitol levels of 23 healthy subjects and 66 diabetic patients were measured enzymatically. Results showed that erythrocyte sorbitol levels of both IDDM (17) and NIDDM (38) patients with poor control were significantly higher than that of the controls and positively correlated with the coincident plasma glucose concentration, 24-hour urinary glucose excretion and HbA1c. There was no significant difference between the red cell sorbitol concentration of NIDDM with normal blood glucose level and that of the normal group; moreover, red cell sorbitol levels did not sig-nificantly correlated with FBG in both groups. Although there was no significant difference between the FBG of poorly controlled IDDM and NIDDM groups, red blood cell sorbitol levels were significantly different in both groups. This suggested that red blood cell sorbitol level could be used as an indicator of diabetic control.

关 键 词：红细胞 山梨醇 糖尿病 糖代谢控制 

分 类 号：R587.102[医药卫生—内分泌]