维生素D缺乏性佝偻病婴幼儿甲状腺和甲状旁腺分泌功能的测定  

MEASUREMENT OF THYROID AND PARATHYROID FUNCTION IN CHILDREN WITH VITAMIN D-DEFICIENT RICKETS

作　　者：孙本华[1] 何光瑞 何玉香[1] 朱云瑞[1] 张慧英[1] 蔡素婴[2] 蒋安惠 秦明镜 陈永红[2] 

机构地区：[1]北京积水潭医院 [2]北京医科大学第一附属医院

出　　处：《中华内分泌代谢杂志》1990年第1期26-28,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：VDR早期和恢复期患儿甲状腺和甲状旁腺分泌功能与正常婴幼儿相比有显著性变化:血T_3和iPTH浓度均明显增高,差异有显著性(P<0.05),而恢复期患儿以血T_4浓度明显增高为显著特点(P<0.05)。婴幼儿在维生素D不缺乏时仍可发生VDR,其发病关键可能在于维生素D活性代谢产物缺乏,特别是1,25(OH)_2D_3的缺乏。另外,T_4/T_3和iPTH/CT分泌比值在对VDR的深入研究中可能有重要临床价值。Thyroid and parathyroid function were significantly changed in children with vitamin D-deficient rickets (VDR) of the early and the recovery stages in comparison with age-matched controls. Serum triiodothyronine (T3) and immunoreactive parathyroid hormone (iPTH) concentrations were significantly elevated (P<0.05), while in the recovery stage the obvious elevation of thyroxine (T4) became characteristic. That the children may still fall ill despite the administration of vitamin D3 and calcium according to the demand of health protection is possibly due to the deficiency of active vitamin D metabolite, especially 1,25-dihydroxyvitamin D. Under the present conditions of health-keeping measures, the children with VDR may recover autonomously. Probably the T4/T3 and iPTH/GT ratio may be clinically valuable in the studies of VDR.

关 键 词：佝偻病 甲状腺 甲状旁腺 分泌功能 

分 类 号：R591.440.2[医药卫生—内科学]