皮质醇增多症病人空肠钙镁吸收功能初步探讨  

A PRELIMINARY STUDY OF JEJUNAL ABSORPTION OF CALCIUM AND MAGNESIUM IN PATIENTS WITH CUSHING'S SYNDROME

作　　者：张克勤[1] 孟迅吾[1] 史轶蘩[1] 贝濂[2] 

机构地区：[1]北京协和医院内分泌科 [2]北京协和医院内科胃肠组

出　　处：《中华内分泌代谢杂志》1990年第1期34-36,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：本文用肠腔灌注和原子吸收光谱分析法测定了6例内源性皮质醇增多症病人空肠对钙和镁的吸收功能。结果与同性别、年龄近似的6例正常对照者比较差异无显著性,空肠钙吸收分别为:-7.89±2.72、-12.50±6.17mg·h^(-1)/30cm(P>0.05);镁吸收分别为-4.47±7.41、+1.61±3.60mg·h^(-1)/30cm(P>0.05)。本组病人与正常组相比较,尿钙排量增多,血钙降低,血浆iPTH增高。初步讨论了这些改变与本病并发骨质疏松的关系。Jejunal absorption of calcium and magnesium was measured with intestinal perfusion technique in 6 normal women and 6 patients with Cushing's syndrome. The calcium and magnesium contents in jejunal fluid were measured by atomic absorption spectrophotometry. The result was that the difference of the mean values of calcium absorption was not significant between the patients and controls (-7.89±2.72 vs -12.5±6.17 mg-h-1/30cm, x±sx, P>0.05). We use ' -' to represent net absorption and ' + ' net secretion. The difference of magnesium absorption between the two groups was also not significant (-4.47±7.41 vs +1.61 ± 3.60 mg-h-1/30 cm,P>0.05). Our data showed that the urinary excretion of calcium in patients was significantly higher than that of 25 controls (P<0.01). The blood levels of calcium and 25OHD in patients were significantly lower than those of the controls (P<0.01) and blood levels of PTH and AKP in patients were significantly higher than those of the controls (P=0.001, <0.01 respectively). These results suggest that increased urinary calcium excretion and secondary hyperparathyroidism may be the cause of osteoporosis in hypercortisolism, whereas the elevated level of cortisol does not cause the malabsorption of calcium and magnesium in our patients with Cushing's syndrome.

关 键 词：皮质醇增多症 肠吸收 钙 镁 

分 类 号：R586.02[医药卫生—内分泌]