磷负荷对糖尿病患者尿蛋白排泄的影响  

THE EFFECT OF PHOSPHATE-LOAD ON URINARY PROTEIN EXCRETION IN DIABETICS

作　　者：周智广[1] 超楚生[1] 伍汉文[1] 

机构地区：[1]湖南医科大学第二附属医院内分泌研究室

出　　处：《中华内分泌代谢杂志》1990年第1期31-33,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：本文观察了14例无氮质血症糖尿病患者磷负荷4周前后的尿蛋白变化。发现磷负荷使血糖控制者尿蛋白排泄增加,血糖未控制者通过磷负荷加常规治疗或单纯常规治疗改善血糖后尿蛋白均减少。血糖控制者经磷负荷尿磷净增值较血糖未控制者高70％。结果提示磷摄入过量具有肾毒性作用,显著高尿磷可能参与糖尿病患者蛋白尿的形成。文中就此探讨了合理补磷治疗糖尿病的问题。The effect of phosphate-load (PL) on urinary protein excretion (UPE) was observed in 14 NIDDM patients without azotemia. All of the patients were with conventional anti-diabetic treatment (CAT). Significant increase of UPE by PL was observed in controlled diabetics (n = 6) with CAT for four weeks, whereas in uncontrolled diabetics with CAT (n = 8) a decrease of UPE was observed. Net increment of urinary phosphate excretion in controlled diabetics was 70% more than that in uncontrolled diabetics after PL. These findings demonstrated that excessive dietary phosphate play a role of nephrotoxicity, and also suggested that hyperphosphaturia was involved in the development of pro-teinuria in diabetics. The problem of appropriate supplement of phosphate for diabetics was discussed.

关 键 词：糖尿病 磷酸盐 肾功能 

分 类 号：R587.102[医药卫生—内分泌]