脑脉康体外抗血小板聚集实验研究  

Experiment Research on Effects of Naomaikang on Anti-Platelet Aggregative in Vitro

作　　者：孙莹[1] 刘晶[2] 庞敏[2] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁省中医药研究院,辽宁沈阳110034

出　　处：《辽宁中医药大学学报》2012年第7期85-87,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省教育厅科学技术研究项目(2008459)

摘　　要：目的:观察脑脉康及其不同极性提取物对体外ADP诱导的家兔的血小板聚集的影响。方法:应用比浊法测定脑脉康及其不同极性提取物的体外抗ADP诱导的血小板聚集率。通过系列浓度,用Logit法计算50%聚集抑制浓度(IC50)。结果:脑脉康及其不同极性提取物有抗血小板聚集作用,其IC50F值为0.5364g.mL-1,其各极性提取物(A^E)IC50值分别为0.00541、0.1248、0.00131、0.00388、0.00308g.mL-1。结论:脑脉康及其不同极性提取物均具有较强的抗血小板聚集作用。Objective： To observe the effects of Naomaikang and the different polarity extracts on platelet aggregation of rabbit induced by ADP in vitro. Methods ： The effects of Naomaikang and the different polarity extracts against platelet aggregation induced by ADP were determined by turbidimetry in a series of concentration, and the IC50 was calculated by Logit method. Results ： The effects of Naomaikang and the different polarity extracts against platelet aggregation induced by ADP were determined, and its lCs0 was 1.250g ~ mL-j , the IC50 of its different polarity extracts （ A-E ）was 0. 0.0048,0.39823,0.00131,0.00313, 0.00286g · mL^-1 respectively. Conclusion ： The results showed that Naomaikang and the different polarity extracts had the effect on antiplatelet aggregation.

关 键 词：脑脉康 不同极性配比提取物 抗血小板聚集 

分 类 号：R965[医药卫生—药理学]