截敏祛风2号方对变应性鼻炎大鼠鼻黏膜组胺的影响  

Experimental Study on Influence of Jiemin Qufeng Decoction Ⅱ on Histamine in Rats of Allergic Rhinitis

作　　者：余亚斌[1] 黄平[1] 马兆鑫[2] 

机构地区：[1]上海中医药大学附属岳阳医院耳鼻喉科,上海200437 [2]上海同济大学附属东方医院耳鼻咽喉科,上海200120

出　　处：《辽宁中医药大学学报》2012年第7期97-99,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：上海市科委课题(05C225)

摘　　要：目的:研究截敏祛风2号方对变应性鼻炎(AR)大鼠的治疗作用和鼻黏膜组胺的影响。方法:50只大鼠随机分为截敏祛风2号方组(A)、截敏祛风汤组(B)、西替利嗪组(C)、模型对照组(D)和正常对照组(E),每组10只。A、B、C及D组经卵清蛋白致敏制备动物模型,A、B和C组分别灌服截敏祛风2号方、截敏祛风汤和西替利嗪,D、E组灌服生理盐水,酶联法检测造模后及治疗后鼻黏膜组胺含量。结果:AR大鼠动物模型制备成功,A、B、C及E组组胺含量均低于D组,A、B、C组与D组比较具有统计学意义(P<0.05);A组与B、C、E组比较无统计学意义(P>0.05)。结论:截敏祛风2号方能降低AR大鼠鼻黏膜中组胺含量,从而阻断变应性鼻炎的发生。Objective ： To investigate the efficacy of Jiemin Qufeng decoction II on treating AR by experimental study and to study the influence on histamine. Methods ： Wistar rats were divided into 5 groups at random, l0 for each group. They were Jiemin Qnfeng decoction II group （A）, Jiemin Qufeng decoction group （ B ）, eetirizine group （ C ）, model control group （ D ） and normal control group （ E ）. AIR rat model was established by OVA except group E. Group A, B and C were administered Jiemin Qufeng decoction II, Jiemin Qufeng decoction and cetirizine respectively;group C and D were given Sodium Chloride. The content of histamine in the nasal mucosa was assayed by ELISA. Results ： The AR ral model was established successfully. The histamine content in group D was remarkably higher than that in other groups. There was statistical significance in group A, B and E compared with group D （ P〈0.05 ）, respectively. No statistically significant differences were detected among group A, B, C and E （ P〉0.05 ）. Conclusions ： Jiemin Qufeng decoction II is effective on AR. It＇s likely to inhibit the release of histamine so as to block up the allergy.

关 键 词：变应性鼻炎 截敏祛风2号方 组胺 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]