高尿酸血症的患病情况及相关因素分析  

Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors

作　　者：陈涛[1] 李卫[1] 王杨[1] 胡泊[1] 徐涛[1] 刘冰[1] 孙毅[1] 

机构地区：[1]中国医学科学院 北京协和医学院 国家心血管病中心 阜外心血管病医院 心血管疾病国家重点实验室 医学研究统计中心,100037

出　　处：《中华临床医师杂志（电子版）》2012年第13期49-52,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的调查我国9省市35～70岁人群高尿酸血症患病率及其相关因素。方法采用整群抽样的方法,调查了15706例居民高尿酸血症患病情况并应用Logistic回归模型分析高尿酸血症的影响因素。结果高尿酸血症的患病率为12.08%(标化后11.57%),其中男性为14.59%(标化后14.84%),女性为10.21%(标化后9.21%);高尿酸血症患病率在女性人群中是随着年龄增长而升高(趋势卡方检验P<0.05),而在男性人群未见明显趋势(趋势卡方检验P>0.05)。高尿酸血症伴发疾病中以高脂血症最为常见(80.40%),其次为超重和肥胖(74.61%)、高血压(58.32%)、腹型肥胖(45.47%)、糖尿病(11.80%);多因素Logistic回归模型显示:年龄(OR=1.01,95%CI:1.01～1.02)、男性(OR=1.36,95%CI:1.21～1.53)、高甘油三酯血症(OR=4.28,95%CI:3.84～4.76)、高胆固醇血症(OR=1.19,95%CI:1.06～1.33)、高血压(OR=1.17,95%CI:1.05～1.30)、肥胖(OR=1.69,95%CI:1.52～1.88)、饮酒(OR=1.36,95%CI:1.19～1.56)与高尿酸血症显著相关。结论高甘油三酯血症、高胆固醇血症、年龄、男性、高血压、肥胖可能为高尿酸血症的危险因素;随着肥胖和代谢综合征发生率的增加以及高尿酸血症与心血病的密切关系,积极控制高尿酸血症对心血管疾病的控制有着十分重要的意义。Objective To investigate the prevalence of hyperuricemia and its risk factors in the adult population aged 35-70 years from 9 provinces. Methods 15 706 residents were recruited from the cross-sectional survey to determine the prevalence of hyperuricemia. Logistic regression model was used to investigate the association between uric acid levels and the various cardiovascular risk factors. Results The prevalence of hyperuricemia was 12. 08% and was higher for men（ 14. 59% ） than women（ 10. 21% ）. The increasing prevalence of hyperuricemia with age can be seen in female population（P 〈 0. 05）, but not in the male population（P 〉 0. 05）. The main concomitant disease of hyperuricemia were hyperlipemia （80.4%）, then overweight and obesity （74.61%）, elevated blood pressure（58. 32% ）, abdomen obesity （45.47%）, diabetes （ 11.80% ）. In a multivariate logistic regression model, age （ OR = 1.01,95 % CI： 1.01-1.02 ）, male gender （ OR = 1.36,95 % CI： 1.21-1.53 ）, obesity （ OR = 1.69,95% CI： 1.52-1.88）, hypertriglyceridemia （ OR = 4. 28,95% CI： 3.84-4. 76 ）, hypercholesteremia （ OR = 1.19,95% CI： 1.06-1.33） ,elevated blood pressure（ OR = 1.17,95% CI： 1.05-1.30）, and drinking（ OR = 1.36,95% CI： 1.19- 1.56） were associated with increased risk of hyperuricemia, Conclusions Hypertriglycedemia, hypercholesteremia, male gender,elevated blood pressure, obesity and drinking are associated with increased risk of hyperuricemia. With the growing incidence of obesity and metabolic syndrome and the positive relationship between hyperuricemia and cardiovascular diseases,we need pay more attention to the control of hyperuricemia.

关 键 词：高尿酸血症 流行病学 危险因素 

分 类 号：R589[医药卫生—内分泌]