右美托咪啶对幕上病灶切除术后患者镇静作用的临床效果观察  

Clinical application of dexmedetomidine for the patients undergoing supratentorial mass lesion postoperation

作　　者：栾翰林[1] 何洹[1] 施冲[1] 刘晓艳[1] 孙梅[1] 

机构地区：[1]广州军区广州总医院麻醉科,510010

出　　处：《中华临床医师杂志（电子版）》2012年第13期90-92,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的观察右美托咪啶应用于幕上病灶切除术后镇静作用的临床效果。方法选择幕上病灶切除术后患者40例(均在麻醉恢复室),年龄18～60岁,随机分为两组,每组20例。试验组:10min静脉泵注右美托咪啶0.8μg/kg后,以0.6μg.kg-1.h-1维持40min;对照组:10min静脉泵注生理盐水10ml后,20ml生理盐水静脉泵注40min。记录患者血压、心率、呼吸等变化,观察给药后患者镇静作用以及不良反应的发生情况。结果试验组给入右美托咪啶后HR、MAP均低于基础值,对比对照组差异具有统计学意义(P<0.05);RR各个时间点则无明显变化;试验组均达到Ramsay镇静分级Ⅳ级状态。结论右美托咪啶(负荷量0.8μg/kg,维持0.6μg.kg-1.h-1)应用于幕上病灶切除术后患者取得了满意的镇静效果。Objective To investigate the clinical sedation efficacy of dexmedetomidine for the patients undergoing supratentorial mass lesion postoperation. Methods 40 cases in the post-anesthesia care unit. ASA physical status I and II. Patients underwent elective supratentorial mass lesion surgery who were randomly divided into two groups. Group A： Dexmedetomidine （an initial dose of 0. 8 μg/kg for 10 mitt, followed by a continuous infusion of 0. 6 μg ·kg^-1·h^-1 ）. Group B ： placebo saline was administered. MAP, HR, SpO2 , RR, Ramesay assessment of sedation and adverse reaction were recorod. Results The hemodynamic status of Group A was more influenced. Adverse reaction was significantly lesser in Group A. The experimental group at different time points on blood pressure, heart rate were lower than the control group, obvious difference in the two groups（P 〈 0. 05 ）. Group A had small influence of MAP and RR. The degree of sedation which 0. 6 μg ·kg^-1·h^-1 produced was quite suitable the clinical practice. Conclusions Dexmedetomidine （ an initial dose of 0. 8 μg/kg for 10 min, followed by a continuous infusion of 0. 6 μg ·kg^-1·h^-1 ） has good sedative for the patients undergoing supratentorial mass lesion postoperation.

关 键 词：右美托咪啶 血流动力学 幕上病灶术后 不良反应 

分 类 号：R651.1[医药卫生—外科学]