白脉软膏对家兔桡骨骨折愈合过程及骨痂骨形态发生蛋白2、碱性成纤维细胞生长因子水平的影响  

Research of Baimai recipe on the fracture healing process and callus BMP2,bFGF expression of rabbit radius fracture model

作　　者：黄有荣[1] 高冠群[1] 杨丽平[2] 陈维武 马渊[2] 

机构地区：[1]广西中医学院附属瑞康医院骨科,南宁530011 [2]中国中医科学院望京医院骨伤药理实验室 [3]西藏奇正藏药有限公司

出　　处：《中华临床医师杂志（电子版）》2012年第13期112-114,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的通过观察外用白脉软膏对家兔桡骨骨折愈合过程的影响,研究白脉软膏改善骨伤愈合的作用及其可能的作用机制。方法机械法建立家兔桡骨骨折动物模型,观察记录实验动物伤腿开始着地及加力着地时间;免疫组化法观察动物骨痂处骨形态发生蛋白2(BMP2)及碱性成纤维细胞生长因子(bFGF)水平。结果外用白脉软膏对骨折模型动物患肢开始着地时间没有影响,但可明显缩短患肢加力着地时间;白脉软膏中及高剂量均可明显升高模型动物骨痂处BMP2及bFGF水平。结论外用白脉软膏对骨折模型动物骨伤愈合过程具有明显的促进作用,其促进骨折愈合作用与调节骨痂处BMP2及bFGF水平有关。Objective To investigate the influence of Baimai recipe on the healing progress of fracture. Methods The bone fracture model was established in the right radius of rabbits. The time for step begin and power step begin were recorded, BMP2, bFGF expressions in callus were detected by immunohistochemistry method. Results Without changing the time of step beginning, Baimai recipe treatment could significantly shorten the time of power step beginning. Baimai recipe increased BMP2 and bFGF expression in callus of fracture animal model. Conclusions The study shows that Baimai recipe could facilitate bone healing progress, Baimai recipe may exert its bone healing effects through modulating BMP2 and bFGF expression in callus.

关 键 词：桡骨骨折 骨折愈合 骨形态发生蛋白质类 成纤维细胞生长因子2 白脉软膏 

分 类 号：R683[医药卫生—骨科学]