AT1R基因多态性与妊娠期高血压疾病相关性的Meta分析  

A meta-analysis of correlation between angiotensin Ⅱ type 1 receptor gene polymorphism and hypertensive disorder complicating pregnancy

作　　者：王芳[1] 平智广[2] 秦玲[1] 彭久君[1] 袁佩[1] 

机构地区：[1]南京医科大学附属常州市妇幼保健院产科,江苏常州213003 [2]郑州大学公共卫生学院卫生统计教研室,河南郑州450001

出　　处：《中国妇幼健康研究》2012年第3期285-288,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨中国人群血管紧张素Ⅱ-1型受体（angiotensin Ⅱ type 1 receptor，AT1R）基因多态性与妊娠期高血压疾病发病的相关性。方法计算机检索中国期刊全文数据库、万方数据库、重庆维普数据库以及Pubmed数据库，检索时间为从建库至20t2年1月。按纳入、排除标准选择纳入有关中国人群AT1R A1166C基因多态性与妊娠期高血压疾病相关性的病例对照研究，评价纳入研究质量，并采用RevMan5．1和Stata11．0软件进行分析。结果共纳入11篇文献，病例组共计862例，对照组共计1142例。AT1R基因1166位点携带变异基因型（AC型＋CC型）的孕妇发生妊娠期高血压疾病的危险增加，合并OR值为2．11，95％c，为1．29～3．46。AT1R基因1166位点携带c等位基因的孕妇发生妊娠期高血压疾病的危险增加，合并OR值为2．02，95％c，为1．29—3．17。结论AT1 RA1166C基因多态性可能与中国人群妊娠期高血压疾病相关，C等位基因可能为妊娠期高血压疾病的致病基因。Objective To investigate the correlation between angiotensin Ⅱ type 1 receptor （AT1R） gene polymorphism and hypertensive disorder complicating pregnancy （HDCP） in Chinese population. Methods CNKI, Wanfang database, VIP, and Pubmed were electronically searched from the very beginning to January 2012. Case-control studies of A1166C gene polymorphism of AT1R and HDCP in Chinese population were included according to inclusion criteria, and the quality of included studies was assessed. The data was quantitatively analyzed with RevMan 5.1 and Stata 11.0 software. Results A total of 11 studies involving 862 patients and 1 142 healthy individuals were included. Pregnant women with mutant genotype AC ＋ CC at 1166 locus of AT1R gene had higher onset risk of HDCP （ OR = 2.11, 95 % CI： 1.29-3.46）, and the allele C carriers also had higher onset risk of HDCP （ OR = 2.02, 95 % CI： 1.29-3.17 ）. Conclusion The A1166C polymorphism of AT1R gene might be associated with HDCP in Chinese population, and the allele C might be a risk factor.

关 键 词：血管紧张素Ⅱ-1型受体 妊娠期高血压疾病 基因多态性 META分析 

分 类 号：R714[医药卫生—妇产科学]